AIMS: To assess the influence of smoking on the type of age related macular degeneration (AMD) lesion causing visual impairment in a large cohort of patients with AMD at a tertiary referral UK centre. METHODS: Prospective, observational, cross sectional study to analyse smoking data on 711 subjects, of western European origin, in relation to the type of AMD lesion present. Colour fundus photographs were graded according to a modified version of the international classification. Multiple logistic regression analysis was performed, adjusting for age and sex using the statistical package SPSS ver 9.0 for Windows. chi(2) tests were also used to assess pack year and ex-smoker data. RESULTS: 578 subjects were graded with neovascular AMD and 133 with non-neovascular AMD. There was no statistically significant association found between smoking status or increasing number of pack years and type of AMD lesion. The odds of "current smokers" compared to "non-smokers" developing neovascular rather than non-neovascular AMD when adjusted for age and sex was 1.88 (95% CI: 0.91 to 3.89; p = 0.09). CONCLUSIONS: Smoking is known to be a risk factor for AMD and this study suggests that smokers are at no more risk of developing neovascular than atrophic lesions.
AIMS: To assess the influence of smoking on the type of age related macular degeneration (AMD) lesion causing visual impairment in a large cohort of patients with AMD at a tertiary referral UK centre. METHODS: Prospective, observational, cross sectional study to analyse smoking data on 711 subjects, of western European origin, in relation to the type of AMD lesion present. Colour fundus photographs were graded according to a modified version of the international classification. Multiple logistic regression analysis was performed, adjusting for age and sex using the statistical package SPSS ver 9.0 for Windows. chi(2) tests were also used to assess pack year and ex-smoker data. RESULTS: 578 subjects were graded with neovascular AMD and 133 with non-neovascular AMD. There was no statistically significant association found between smoking status or increasing number of pack years and type of AMD lesion. The odds of "current smokers" compared to "non-smokers" developing neovascular rather than non-neovascular AMD when adjusted for age and sex was 1.88 (95% CI: 0.91 to 3.89; p = 0.09). CONCLUSIONS: Smoking is known to be a risk factor for AMD and this study suggests that smokers are at no more risk of developing neovascular than atrophic lesions.
Authors: Hendrik P N Scholl; Samantha S Dandekar; Tunde Peto; Catey Bunce; Wen Xing; Sharon Jenkins; Alan C Bird Journal: Ophthalmology Date: 2004-01 Impact factor: 12.079
Authors: Ivan J Suñer; Diego G Espinosa-Heidmann; Maria E Marin-Castano; Eleut P Hernandez; Simone Pereira-Simon; Scott W Cousins Journal: Invest Ophthalmol Vis Sci Date: 2004-01 Impact factor: 4.799
Authors: Gareth J McKay; Chris C Patterson; Usha Chakravarthy; Shilpa Dasari; Caroline C Klaver; Johannes R Vingerling; Lintje Ho; Paulus T V M de Jong; Astrid E Fletcher; Ian S Young; Johan H Seland; Mati Rahu; Gisele Soubrane; Laura Tomazzoli; Fotis Topouzis; Jesus Vioque; Aroon D Hingorani; Reecha Sofat; Michael Dean; Julie Sawitzke; Johanna M Seddon; Inga Peter; Andrew R Webster; Anthony T Moore; John R W Yates; Valentina Cipriani; Lars G Fritsche; Bernhard H F Weber; Claudia N Keilhauer; Andrew J Lotery; Sarah Ennis; Michael L Klein; Peter J Francis; Dwight Stambolian; Anton Orlin; Michael B Gorin; Daniel E Weeks; Chia-Ling Kuo; Anand Swaroop; Mohammad Othman; Atsuhiro Kanda; Wei Chen; Goncalo R Abecasis; Alan F Wright; Caroline Hayward; Paul N Baird; Robyn H Guymer; John Attia; Ammarin Thakkinstian; Giuliana Silvestri Journal: Hum Mutat Date: 2011-09-12 Impact factor: 4.878
Authors: Gareth J McKay; Giuliana Silvestri; Usha Chakravarthy; Shilpa Dasari; Lars G Fritsche; Bernhard H Weber; Claudia N Keilhauer; Michael L Klein; Peter J Francis; Caroline C Klaver; Johannes R Vingerling; Lintje Ho; Paulus T D V De Jong; Michael Dean; Julie Sawitzke; Paul N Baird; Robyn H Guymer; Dwight Stambolian; Anton Orlin; Johanna M Seddon; Inga Peter; Alan F Wright; Caroline Hayward; Andrew J Lotery; Sarah Ennis; Michael B Gorin; Daniel E Weeks; Chia-Ling Kuo; Aroon D Hingorani; Reecha Sofat; Valentina Cipriani; Anand Swaroop; Mohammad Othman; Atsuhiro Kanda; Wei Chen; Goncalo R Abecasis; John R Yates; Andrew R Webster; Anthony T Moore; Johan H Seland; Mati Rahu; Gisele Soubrane; Laura Tomazzoli; Fotis Topouzis; Jesus Vioque; Ian S Young; Astrid E Fletcher; Chris C Patterson Journal: Am J Epidemiol Date: 2011-04-15 Impact factor: 4.897