Literature DB >> 16597440

Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship.

Natsue Yoshimura1, Daisuke Horiuchi, Masao Shibata, Minoru Saitoe, Mei-Ling Qi, Hitoshi Okazawa.   

Abstract

Frame shift mutations of the polyglutamine binding protein-1 (PQBP1) gene lead to total or partial truncation of the C-terminal domain (CTD) and cause mental retardation in human patients. Interestingly, normal Drosophila homologue of PQBP-1 lacks CTD. As a model to analyze the molecular network of PQBP-1 affecting intelligence, we generated transgenic flies expressing human PQBP-1 with CTD. Pavlovian olfactory conditioning revealed that the transgenic flies showed disturbance of long-term memory. In addition, they showed abnormal courtship that male flies follow male flies. Abnormal functions of PQBP-1 or its binding partner might be linked to these symptoms.

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Year:  2006        PMID： 16597440     DOI： 10.1016/j.febslet.2006.03.056

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Epigenetic principles and mechanisms underlying nervous system functions in health and disease.

Authors:  Mark F Mehler
Journal:  Prog Neurobiol       Date:  2008-10-17       Impact factor: 11.685

2.  Solution model of the intrinsically disordered polyglutamine tract-binding protein-1.

Authors:  Martin Rees; Christian Gorba; Cesira de Chiara; Tam T T Bui; Mitla Garcia-Maya; Alex F Drake; Hitoshi Okazawa; Annalisa Pastore; Dmitri Svergun; Yu Wai Chen
Journal:  Biophys J       Date:  2012-04-03       Impact factor: 4.033

3.  Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning.

Authors:  Takuya Tamura; Daisuke Horiuchi; Yi-Chung Chen; Masaki Sone; Tomoyuki Miyashita; Minoru Saitoe; Natsue Yoshimura; Ann-Shyn Chiang; Hitoshi Okazawa
Journal:  J Neurosci       Date:  2010-10-20       Impact factor: 6.167

4.  Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing.

Authors:  Victor E Tapia; Emilia Nicolaescu; Caleb B McDonald; Valeria Musi; Tsutomu Oka; Yujin Inayoshi; Adam C Satteson; Virginia Mazack; Jasper Humbert; Christian J Gaffney; Monique Beullens; Charles E Schwartz; Christiane Landgraf; Rudolf Volkmer; Annalisa Pastore; Amjad Farooq; Mathieu Bollen; Marius Sudol
Journal:  J Biol Chem       Date:  2010-04-21       Impact factor: 5.157

Review 5.  PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity.

Authors:  Hikari Tanaka; Hitoshi Okazawa
Journal:  Int J Mol Sci       Date:  2022-06-02       Impact factor: 6.208

6.  Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster.

Authors:  Holly LaFerriere; Douglas J Guarnieri; Divya Sitaraman; Soeren Diegelmann; Ulrike Heberlein; Troy Zars
Journal:  Genetics       Date:  2008-04       Impact factor: 4.562

7.  The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling.

Authors:  Yasuno Iwasaki; Gerald H Thomsen
Journal:  Development       Date:  2014-09-10       Impact factor: 6.868

8.  Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression.

Authors:  Risa Shiraishi; Takuya Tamura; Masaki Sone; Hitoshi Okazawa
Journal:  PLoS One       Date:  2014-12-31       Impact factor: 3.240

9.  Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism.

Authors:  Keiko Takahashi; Sawako Yoshina; Maekawa Masashi; Wakana Ito; Takao Inoue; Hiroki Shiwaku; Hiroyuki Arai; Shohei Mitani; Hitoshi Okazawa
Journal:  PLoS One       Date:  2009-01-01       Impact factor: 3.240
  9 in total

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