Literature DB >> 16596775

Modulators of endocannabinoid enzymic hydrolysis and membrane transport.

W S V Ho1, C J Hillard.   

Abstract

Tissue concentrations of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are regulated by both synthesis and inactivation. The purpose of this review is to compile available data regarding three inactivation processes: fatty acid amide hydrolase, monoacylglycerol lipase, and cellular membrane transport. In particular, we have focused on mechanisms by which these processes are modulated. We describe the in vitro and in vivo effects of inhibitors of these processes as well as available evidence regarding their modulation by other factors.

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Year:  2005        PMID： 16596775     DOI： 10.1007/3-540-26573-2_6

Source DB:  PubMed          Journal:  Handb Exp Pharmacol        ISSN： 0171-2004


  14 in total

Review 1.  The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids.

Authors:  Roger G Pertwee
Journal:  AAPS J       Date:  2005-10-24       Impact factor: 4.009

2.  Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.

Authors:  Bin Pan; Wei Wang; Jonathan Z Long; Dalong Sun; Cecilia J Hillard; Benjamin F Cravatt; Qing-song Liu
Journal:  J Pharmacol Exp Ther       Date:  2009-08-07       Impact factor: 4.030

3.  Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity.

Authors:  Matthias Blüher; Stefan Engeli; Nora Klöting; Janin Berndt; Mathias Fasshauer; Sándor Bátkai; Pál Pacher; Michael R Schön; Jens Jordan; Michael Stumvoll
Journal:  Diabetes       Date:  2006-11       Impact factor: 9.461

Review 4.  Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence.

Authors:  C J Hillard; K M Weinlander; K L Stuhr
Journal:  Neuroscience       Date:  2011-11-17       Impact factor: 3.590

5.  Role of endocannabinoid signaling in anxiety and depression.

Authors:  Sachin Patel; Cecilia J Hillard
Journal:  Curr Top Behav Neurosci       Date:  2009

6.  Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans.

Authors:  Andrea Dlugos; Emma Childs; Kara L Stuhr; Cecilia J Hillard; Harriet de Wit
Journal:  Neuropsychopharmacology       Date:  2012-07-04       Impact factor: 7.853

7.  Expression and function of fatty acid amide hydrolase in prostate cancer.

Authors:  Michael P Endsley; Rebecca Thill; Iffat Choudhry; Carol L Williams; Andre Kajdacsy-Balla; William B Campbell; Kasem Nithipatikom
Journal:  Int J Cancer       Date:  2008-09-15       Impact factor: 7.396

8.  Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats.

Authors:  W-S Vanessa Ho; Sheila M Gardiner
Journal:  Br J Pharmacol       Date:  2009-01       Impact factor: 8.739

9.  The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet.

Authors:  V Di Marzo; R Capasso; I Matias; G Aviello; S Petrosino; F Borrelli; B Romano; P Orlando; F Capasso; A A Izzo
Journal:  Br J Pharmacol       Date:  2008-01-28       Impact factor: 8.739

10.  Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon.

Authors:  Angelo A Izzo; Gabriella Aviello; Stefania Petrosino; Pierangelo Orlando; Giovanni Marsicano; Beat Lutz; Francesca Borrelli; Raffaele Capasso; Santosh Nigam; Francesco Capasso; Vincenzo Di Marzo
Journal:  J Mol Med (Berl)       Date:  2007-09-06       Impact factor: 4.599
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