Literature DB >> 16596174

Anti-tumor effects of herbal medicines on endometrial carcinomas via estrogen receptor-alpha-related mechanism.

Zenglin Lian1, Kenji Niwa, Kyoko Onogi, Hideki Mori, Rosanne C Harrigan, Teruhiko Tamaya.   

Abstract

This study was performed to examine the relationship between the anti-tumor effects of herbal medicine and endometrial carcinoma with ER-related mechanisms. An endometrial cancer cell line (Ishikawa) was used for this study. The cell viability and expression of estrogen receptors (ER) were determined by MTT and RT-PCR. A dose-dependent decrease of viability and apoptosis of the cancer cells was generated by exposure to the herbal medicines, Juzen-taiho-to or Shimotsu-to. The expression of ER-alpha mRNA, but not ER-beta mRNA was suppressed by Juzen-taiho-to or Shimotsu-to in an endometrial cancer cell line. The anti-tumor effect of these herbal medicines against endometrial carcinoma might be correlated to the ER-alpha related mechanism.

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Year:  2006        PMID： 16596174

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   3.906


  5 in total

1.  Microarray analysis on germfree mice elucidates the primary target of a traditional Japanese medicine juzentaihoto: acceleration of IFN-α response via affecting the ISGF3-IRF7 signaling cascade.

Authors:  Kaori Munakata; Kiyoe Takashima; Mitsue Nishiyama; Naoko Asano; Akihito Mase; Kyoji Hioki; Yasuyuki Ohnishi; Masahiro Yamamoto; Kenji Watanabe
Journal:  BMC Genomics       Date:  2012-01-18       Impact factor: 3.969

2.  Traditional Chinese medicinal formula Si-Wu-Tang prevents oxidative damage by activating Nrf2-mediated detoxifying/antioxidant genes.

Authors:  Mandy Liu; Ranadheer Ravula; Zhijun Wang; Zhong Zuo; Moses Ss Chow; Arvind Thakkar; Sunil Prabhu; Bradley Andresen; Ying Huang
Journal:  Cell Biosci       Date:  2014-02-10       Impact factor: 7.133

3.  Inhibition of Neoplastic Transformation and Chemically-Induced Skin Hyperplasia in Mice by Traditional Chinese Medicinal Formula Si-Wu-Tang.

Authors:  Mandy M Liu; Kevin M Huang; Steven Yeung; Andy Chang; Suhui Zhang; Nan Mei; Cyrus Parsa; Robert Orlando; Ying Huang
Journal:  Nutrients       Date:  2017-03-18       Impact factor: 5.717

4.  Use of herbal dietary supplement si-wu-tang and health-related quality of life in postpartum women: a population-based correlational study.

Authors:  Pei-Jen Chang; Ching-Chun Lin; Yi Chun Chen; Chao-Hua Chuang; Yu-Ching Tseng; Wu-Shiun Hsieh; Shio-Jean Lin; Pau-Chung Chen
Journal:  Evid Based Complement Alternat Med       Date:  2013-02-14       Impact factor: 2.629

5.  Transcriptional profiling of Chinese medicinal formula Si-Wu-Tang on breast cancer cells reveals phytoestrogenic activity.

Authors:  Mandy Liu; Jeffery Fan; Steven Wang; Zhijun Wang; Charles Wang; Zhong Zuo; Moses S S Chow; Leming Shi; Zhining Wen; Ying Huang
Journal:  BMC Complement Altern Med       Date:  2013-01-10       Impact factor: 3.659
  5 in total

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