OBJECTIVE: The erythrocyte binding antigen 175 kDa (EBA-175) of Plasmodium falciparum is one of the major ligands for red blood cell invasion by merozoites. EBA-175 is a dimorphic antigen but the role that dimorphism plays in host parasite interaction is not fully understood. In this study, we sought to determine the distribution of EBA-175 genotypes and its pathogenetic influence. METHODS: The nested polymerase chain reaction was used to determine the genotypes of P. falciparum isolates from asymptomatic and symptomatic Gabonese children. RESULTS: CAMP strains (C-segment) and FCR-3 strains (F-segment) were found in 13/50 (26%) and 19/50 (38%) symptomatic children, respectively and in 16/66 (24%) and 46/66 (70%) asymptomatic children, respectively. The prevalence of mixed C-/F- infection was 18/50 (36%) and 4/66 (6%) in symptomatic and asymptomatic children, respectively. CONCLUSIONS: These results show that mixed C-/F- infection is associated with clinical malaria (chi2, P <0.01) and may have important therapeutic implications.
OBJECTIVE: The erythrocyte binding antigen 175 kDa (EBA-175) of Plasmodium falciparum is one of the major ligands for red blood cell invasion by merozoites. EBA-175 is a dimorphic antigen but the role that dimorphism plays in host parasite interaction is not fully understood. In this study, we sought to determine the distribution of EBA-175 genotypes and its pathogenetic influence. METHODS: The nested polymerase chain reaction was used to determine the genotypes of P. falciparum isolates from asymptomatic and symptomatic Gabonese children. RESULTS:CAMP strains (C-segment) and FCR-3 strains (F-segment) were found in 13/50 (26%) and 19/50 (38%) symptomatic children, respectively and in 16/66 (24%) and 46/66 (70%) asymptomatic children, respectively. The prevalence of mixed C-/F- infection was 18/50 (36%) and 4/66 (6%) in symptomatic and asymptomatic children, respectively. CONCLUSIONS: These results show that mixed C-/F- infection is associated with clinical malaria (chi2, P <0.01) and may have important therapeutic implications.
Authors: T R Jones; D L Narum; A S Gozalo; J Aguiar; S R Fuhrmann; H Liang; J D Haynes; J K Moch; C Lucas; T Luu; A J Magill; S L Hoffman; B K Sim Journal: J Infect Dis Date: 2000-12-08 Impact factor: 5.226
Authors: Janine Stubbs; Ken M Simpson; Tony Triglia; David Plouffe; Christopher J Tonkin; Manoj T Duraisingh; Alexander G Maier; Elizabeth A Winzeler; Alan F Cowman Journal: Science Date: 2005-08-26 Impact factor: 47.728
Authors: H A Babiker; A M Creasey; B Fenton; R A Bayoumi; D E Arnot; D Walliker Journal: Trans R Soc Trop Med Hyg Date: 1991 Sep-Oct Impact factor: 2.184
Authors: Fousseyni S Touré; Jérôme Mezui-Me-Ndong; Odile Ouwe-Missi-Oukem-Boyer; Benjamin Ollomo; Dominique Mazier; Sylvie Bisser Journal: Clin Med Res Date: 2006-09
Authors: Issiaka Soulama; Edith C Bougouma; Amidou Diarra; Issa Nebie; Sodiomon B Sirima Journal: Trop Med Int Health Date: 2009-11-03 Impact factor: 2.622
Authors: Fousseyni S Touré; Odile Ouwe-Missi-Oukem-Boyer; Jérôme Mezui-Me-Ndong; Guy Roger Ndong-Atome; Ulrick Bisvigou; Dominique Mazier; Sylvie Bisser Journal: Clin Med Res Date: 2007-06
Authors: Daiana S Perce-da-Silva; Dalma M Banic; Josué C Lima-Junior; Fátima Santos; Cláudio T Daniel-Ribeiro; Joseli de Oliveira-Ferreira; Lilian R Pratt-Riccio Journal: Malar J Date: 2011-05-26 Impact factor: 2.979
Authors: Issiaka Soulama; Jude D Bigoga; Magatte Ndiaye; Edith C Bougouma; Josephine Quagraine; Prisca N Casimiro; Timothy T Stedman; Sodiomon B Sirima Journal: Am J Trop Med Hyg Date: 2011-02 Impact factor: 2.345
Authors: Dolie D Laishram; Patrick L Sutton; Nutan Nanda; Vijay L Sharma; Ranbir C Sobti; Jane M Carlton; Hema Joshi Journal: Malar J Date: 2012-01-31 Impact factor: 2.979
Authors: Hamza B Abagna; Festus K Acquah; Ruth Okonu; Nii A Aryee; Michael Theisen; Linda E Amoah Journal: Malar J Date: 2018-01-08 Impact factor: 2.979
Authors: Issiaka Soulama; Samuel S Sermé; Edith C Bougouma; Amidou Diarra; Alfred B Tiono; Alphonse Ouedraogo; Amadou T Konate; Issa Nebie; Sodiomon B Sirima Journal: J Parasitol Res Date: 2015-11-08
Authors: Ahmed A M Adam; Ahmed A A Amine; Dina A Hassan; Waleed H Omer; Bakri Y Nour; Arulanantham Zechariah Jebakumar; Muntaser E Ibrahim; Nasreldin H Abdulhadi; Hiba S Mohamed Journal: BMC Infect Dis Date: 2013-10-09 Impact factor: 3.090