| Literature DB >> 16595160 |
María J Bullido1, Ana Martínez-García, María J Artiga, Jesús Aldudo, Isabel Sastre, Pedro Gil, Francisco Coria, David G Muñoz, Vladimir Hachinski, Ana Frank, Fernando Valdivieso.
Abstract
Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD.Entities:
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Year: 2006 PMID： 16595160 DOI： 10.1016/j.neurobiolaging.2006.02.011
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673