Literature DB >> 16595068

Leaching of diethylhexyl phthalate from polyvinyl chloride materials into etoposide intravenous solutions.

Mário L de Lemos1, Linda Hamata, Thanh Vu.   

Abstract

Etoposide intravenous solution is associated with leaching of diethylhexyl phthalate (DEHP) from bags and tubings made from polyvinyl chloride (PVC). Recent evidence suggests that this may be more substantial than previously found. Since DEHP is potentially hepatotoxic and carcinogenic, it is preferable to prepare and administer etoposide bags and tubings made from non-PVC materials.

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Year:  2005        PMID: 16595068     DOI: 10.1191/1078155205jp164oa

Source DB:  PubMed          Journal:  J Oncol Pharm Pract        ISSN: 1078-1552            Impact factor:   1.809


  2 in total

1.  DEHP Nanodroplets Leached From Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum.

Authors:  Jared R Snell; Connor R Monticello; Cheng Her; Emma L Ross; Ashley A Frazer-Abel; John F Carpenter; Theodore W Randolph
Journal:  J Pharm Sci       Date:  2019-06-21       Impact factor: 3.534

2.  Adsorption and Leachable Contamination of Flucloxacillin, Cyclosporin and Amiodarone Following Delivery Through an Intravenous Administration Set.

Authors:  Zachary Woodward; Peter Brooks; Bernadette Morris-Smith; Marianne Wallis; Steven M Ogbourne
Journal:  Pharm Res       Date:  2018-04-19       Impact factor: 4.200

  2 in total

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