[Some aspects of gallbladder carcinogenesis].

Gallbladder carcinoma is an uncommon but highly malignant tumor with a poor survival rate. The coincidence of gallstones, especially those with a diameter over 3 cm and gallbladder carcinoma is well established. Anomalous junction of pancreaticobiliary ducts (AJPBD) is an additional risk factor for gallbladder malignancy. Those conditions followed by chronic inflammation lead to many molecular disturbances in the cell cycle of the gallbladder mucosa and make the tumorigenesis possible.