Literature DB >> 16593564

Regulation of methionine synthesis in Escherichia coli: Effect of metJ gene product and S-adenosylmethionine on the expression of the metF gene.

R Shoeman1, B Redfield, T Coleman, R C Greene, A A Smith, N Brot, H Weissbach.   

Abstract

The regulation of the expression of the Escherichia coli metF gene, which codes for 5,10-methylenetet-rahydrofolate reductase (EC 1.1.99.15), has been investigated by using a simplified DNA-directed in vitro system that measures the formation of the first dipeptide (fMet-Ser) of the gene product. The synthesis of fMet-Ser directed by a plasmid containing the metF gene is specifically inhibited by metJ protein (repressor protein). S-Adenosylmethionine enhances the inhibition by the metJ protein of metF gene expression. The inhibition by the metJ protein is at the level of transcription and the results suggest that S-adenosylmethionine is functioning as an allosteric effector.

Entities:  

Year:  1985        PMID： 16593564      PMCID： PMC397833          DOI： 10.1073/pnas.82.11.3601

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  Purification and properties of a soluble factor required for the deoxyribonucleic acid-directed in vitro synthesis of beta-galactosidase.

Authors:  H Kung; C Spears; H Weissbach
Journal:  J Biol Chem       Date:  1975-02-25       Impact factor: 5.157

2.  DNA-directed in vitro synthesis of proteins involved in bacterial transcription and translation.

Authors:  T Zarucki-Schulz; C Jerez; G Goldberg; H F Kung; K H Huang; N Brot; H Weissbach
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

3.  Properties of metK mutants of Escherichia coli K-12.

Authors:  R C Greene; J S Hunter; E H Coch
Journal:  J Bacteriol       Date:  1973-07       Impact factor: 3.490

4.  Regulation of the terminal reactions in methionine biosynthesis by vitamin B 12 and methionine.

Authors:  H F Kung; C Spears; R C Greene; H Weissbach
Journal:  Arch Biochem Biophys       Date:  1972-05       Impact factor: 4.013

5.  Methods for the analysis and preparation of adenosylmethionine and adenosylhomocysteine.

Authors:  S K Shapiro; D J Ehninger
Journal:  Anal Biochem       Date:  1966-05       Impact factor: 3.365

6.  S-Adenosylmethionine synthetase deficient mutants of Escherichia coli K-12 with impaired control of methionine biosynthesis.

Authors:  R C Greene; C H Su; C T Holloway
Journal:  Biochem Biophys Res Commun       Date:  1970-03-27       Impact factor: 3.575

7.  Isolation and some properties of methionine transfer ribonucleic acid from Escherichia coli.

Authors:  P Schofield
Journal:  Biochemistry       Date:  1970-04-14       Impact factor: 3.162

8.  Regulation by methionine of the synthesis of a third aspartokinase and of a second homoserine dehydrogenase in Escherichia coli K 12.

Authors:  J C Patte; G Le Bras; G N Cohen
Journal:  Biochim Biophys Acta       Date:  1967-03-22

9.  Effect of L-methionine and vitamin B 12 on methionine biosynthesis in Escherichia coli.

Authors:  L Milner; C Whitfield; H Weissbach
Journal:  Arch Biochem Biophys       Date:  1969-09       Impact factor: 4.013

10.  DNA-directed in vitro synthesis of beta-galactosidase. Studies with purified factors.

Authors:  H F Kung; B Redfield; B V Treadwell; B Eskin; C Spears; H Weissbach
Journal:  J Biol Chem       Date:  1977-10-10       Impact factor: 5.157
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  25 in total

1.  Structure-function studies on Escherichia coli MetR protein, a putative prokaryotic leucine zipper protein.

Authors:  M E Maxon; J Wigboldus; N Brot; H Weissbach
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

2.  Characterization of two mutant metJ proteins with reduced, temperature-dependent capacity to regulate Escherichia coli K-12 met regulon elements.

Authors:  G A Bala; C D Collier; M R Emmett; J R Johnson
Journal:  J Bacteriol       Date:  1989-07       Impact factor: 3.490

3.  MetJ repressor interactions with DNA probed by in-cell NMR.

Authors:  Anne M Augustus; Patrick N Reardon; Leonard D Spicer
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-16       Impact factor: 11.205

4.  Regulation of in vivo transcription of the Escherichia coli K-12 metJBLF gene cluster.

Authors:  T W Kirby; B R Hindenach; R C Greene
Journal:  J Bacteriol       Date:  1986-03       Impact factor: 3.490

5.  The Escherichia coli K-12 metJ193 allele contains a point mutation which alters the hydrophobic pocket responsible for in vitro binding of S-adenosylmethionine: effects on cell growth and induction of met regulon expression.

Authors:  C D Collier; J R Johnson
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

6.  Methionine synthesis in Escherichia coli: effect of the MetR protein on metE and metH expression.

Authors:  X Y Cai; M E Maxon; B Redfield; R Glass; N Brot; H Weissbach
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

7.  Nucleotide sequence of the Salmonella typhimurium metR gene and the metR-metE control region.

Authors:  L S Plamann; G V Stauffer
Journal:  J Bacteriol       Date:  1987-09       Impact factor: 3.490

8.  Isolation and characterization of the product of the methionine-regulatory gene metJ of Escherichia coli K-12.

Authors:  A A Smith; R C Greene; T W Kirby; B R Hindenach
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

9.  Discrimination between closely related cellular metabolites by the SAM-I riboswitch.

Authors:  Rebecca K Montange; Estefanía Mondragón; Daria van Tyne; Andrew D Garst; Pablo Ceres; Robert T Batey
Journal:  J Mol Biol       Date:  2009-12-16       Impact factor: 5.469

10.  S-methylmethionine metabolism in Escherichia coli.

Authors:  M Thanbichler; B Neuhierl; A Böck
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490
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