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Literature DB >> 1659352

Phorbol ester cardiotoxicity: are .O2-radicals involved?

Abstract

The effect of superoxide dismutase (SOD) on cardiotoxic effects induced by phorbol 12-myristate 13-acetate (PMA) was investigated in isolated perfused rat hearts. The negative inotropic effect, vasoconstriction, and mild bradycardia were uneffected by SOD in the perfusion medium. Perfusion of Langendorff hearts with PMA and oxidized cytochrome c +/- SOD gave no evidence for a formation of .O2 radicals in response to PMA. Cytochrome c reduction detected in the perfusate of PMA-treated Langendorff hearts is not inhibited by SOD and has thus to be attributed to .O2-independent myocardial reducing systems.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1991 PMID： 1659352 DOI： 10.1007/bf01968969

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

25 in total

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Authors: K Müller
Journal: Pharm Unserer Zeit Date: 1988-05

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Authors: W G Nayler; J S Elz
Journal: Circulation Date: 1986-08 Impact factor: 29.690

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Authors: J C Fantone; P A Ward
Journal: Am J Pathol Date: 1982-06 Impact factor: 4.307

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Authors: Y Nishizuka
Journal: Science Date: 1986-07-18 Impact factor: 47.728

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Authors: I Fridovich
Journal: Arch Biochem Biophys Date: 1986-05-15 Impact factor: 4.013

7. Effect of atenolol and pindolol on the phorbol ester-induced coronary vasoconstriction in the isolated perfused heart of the rat.

Authors: H Ruskoaho
Journal: Br J Pharmacol Date: 1988-06 Impact factor: 8.739

Phorbol ester cardiotoxicity: are .O2-radicals involved?

Review 1. [Active oxygen species. Significance for disease and health].

2. Coronary and myocardial effects of activated neutrophils in perfused rabbit hearts.

3. Reperfusion injury: laboratory artifact or clinical dilemma?

4. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

Review 5. Studies and perspectives of protein kinase C.

Review 6. Biological effects of the superoxide radical.

7. Effect of atenolol and pindolol on the phorbol ester-induced coronary vasoconstriction in the isolated perfused heart of the rat.

8. Effect of extracellular calcium on vascular contraction induced by phorbol ester.

9. Effect of some free radical scavengers on reperfusion induced arrhythmias in the isolated rat heart.

10. Phorbol dibutyrate inhibits release and action of endothelium-derived relaxing factor(s) in canine blood vessels.

1. Leukocytic .O2- and cardiac dysfunctions in isolated perfused rat hearts.