Derivation of the relation between the linear Onsager coefficients and the equilibrium one-way cycle fluxes of a biochemical kinetic diagram.

The Onsager flux-force coefficients L(ij) for any biochemical system at a steady state near equilibrium have a simple interpretation: they are linear combinations of the equilibrium one-way cycle fluxes of the kinetic diagram for the system. An explicit and general expression for L(ij) is derived. This supplements the more pedagogical argument published elsewhere, which was based on a particular special case.