Literature DB >> 1659314

Drug testing for activity against varicella-zoster virus in hairless guinea pigs.

M G Myers1, L R Stanberry.   

Abstract

Inoculation of congenitally hairless guinea pigs with varicella-zoster virus (VZV) (Oka strain) results in a self-limited exanthematous infection analogous to varicella in children. Administration of acyclovir or 6-methoxypurine arabinoside modified the course of infection. This model should facilitate pre-clinical testing of putative anti-VZV agents.

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Year:  1991        PMID： 1659314     DOI： 10.1016/0166-3542(91)90015-j

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  5 in total

Review 1.  Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.

Authors:  A J Wagstaff; D Faulds; K L Goa
Journal:  Drugs       Date:  1994-01       Impact factor: 9.546

2.  Varicella zoster virus (VZV) infects and establishes latency in enteric neurons.

Authors:  Jason J Chen; Anne A Gershon; Zhishan Li; Robert A Cowles; Michael D Gershon
Journal:  J Neurovirol       Date:  2011-12-22       Impact factor: 3.739

3.  Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models.

Authors:  Paul R Kinchington; William F Goins
Journal:  J Neurovirol       Date:  2011-12-28       Impact factor: 3.739

Review 4.  Current pharmacological approaches to the therapy of varicella zoster virus infections: a guide to treatment.

Authors:  R Snoeck; G Andrei; E De Clercq
Journal:  Drugs       Date:  1999-02       Impact factor: 11.431

5.  Infected peripheral blood mononuclear cells transmit latent varicella zoster virus infection to the guinea pig enteric nervous system.

Authors:  Lin Gan; Mingli Wang; Jason J Chen; Michael D Gershon; Anne A Gershon
Journal:  J Neurovirol       Date:  2014-06-26       Impact factor: 3.739
  5 in total

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