Literature DB >> 16592969

Solution conformation of gramicidin S: An intramolecular nuclear Overhauser effect study.

D H Huang1, R Walter, J D Glickson, N R Krishna.   

Abstract

The solution conformation of gramicidin S in deuterated dimethyl sulfoxide was investigated by using the intramolecular nuclear Overhauser effect experiment. Experimental Overhauser enhancements were compared with predicted values for each of the nine most-stable conformations (M1-M9) calculated by Dygert et al. on the basis of energy-minimization procedures [Dygert, M., Gō, N. & Scheraga, H. A. (1975) Macromolecules 8, 750-761]. By using statistical hypothesis testing, the three lowest-energy conformations (M1, M2, and M3) were shown to give the best fit with the experimental data. All other conformations (M4-M9) were found to be inconsistent with the experimental data.

Entities:  

Year:  1981        PMID： 16592969      PMCID： PMC319861          DOI： 10.1073/pnas.78.2.672

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Lanthanide induced NMR perturbations of HEW lysozyme: evidence for nonaxial symmetry.

Authors:  D G Agresti; R E Lenkinski; J D Glickson
Journal:  Biochem Biophys Res Commun       Date:  1977-06-06       Impact factor: 3.575

2.  Pulsed FT-NMR double resonance studies of yeast tRNAPhe: specific nuclear Overhauser effects and reinterpretation of low temperature relaxation data.

Authors:  P D Johnston; A G Redfield
Journal:  Nucleic Acids Res       Date:  1978-10       Impact factor: 16.971

3.  Individual residue correlation times of peptides from proton relaxation parameters: application to gramicidin S.

Authors:  C R Jones; C T Sikakana; S P Hehir; W A Gibbons
Journal:  Biochem Biophys Res Commun       Date:  1978-08-29       Impact factor: 3.575

4.  The quantitation of nuclear Overhauser effect methods for total conformational analysis of peptides in solution. Application to gramicidin S.

Authors:  C R Jones; C T Sikakana; S Hehir; M C Kuo; W A Gibbons
Journal:  Biophys J       Date:  1978-12       Impact factor: 4.033

5.  Nuclear Overhauser effects and the conformation of gramicidin S.

Authors:  I D Rae; E R Stimson; H A Scheraga
Journal:  Biochem Biophys Res Commun       Date:  1977-07-11       Impact factor: 3.575

6.  Use of a symmetry condition to compute the conformation of gramicidin S1.

Authors:  M Dygert; N Gō; H A Scheraga
Journal:  Macromolecules       Date:  1975 Nov-Dec       Impact factor: 5.985

7.  Multiple solution conformations and internal rotations of the decapeptide gramicidin S.

Authors:  C R Jones; M Kuo; W A Gibbons
Journal:  J Biol Chem       Date:  1979-10-25       Impact factor: 5.157

8.  Simplification and spin-spin analysis of the side chain proton magnetic resonance spectrum of the decapeptide gramicidin S using difference scalar decoupling and biosynthesis of specifically deuterated analogs.

Authors:  M Kuo; C R Jones; T H Mahn; P R Miller; L J Nicholls; W A Gibbons
Journal:  J Biol Chem       Date:  1979-10-25       Impact factor: 5.157

9.  Intramolecular 1H nuclear Overhauser effect study of the solution conformation of valinomycin in dimethyl sulfoxide.

Authors:  J D Glickson; S L Gordon; P Pitner; D G Agresti; R Walter
Journal:  Biochemistry       Date:  1976-12-28       Impact factor: 3.162

10.  Solution conformation of peptides by the intramolecular nuclear Overhauser effect experiment. Study of valinomycin-K+.

Authors:  N R Krishna; D G Agresti; J D Glickson; R Walter
Journal:  Biophys J       Date:  1978-12       Impact factor: 4.033
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  1 in total

1.  A variable target intensity-restrained global optimization (VARTIGO) procedure for determining three-dimensional structures of polypeptides from NOESY data: application to gramicidin-S.

Authors:  Y Xu; I P Sugár; N R Krishna
Journal:  J Biomol NMR       Date:  1995-01       Impact factor: 2.835
  1 in total

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