| Literature DB >> 16592839 |
T L Lai1, B Levin, H Robbins, D Siegmund.
Abstract
A model for sequential clinical trials is discussed. Three proposed stopping rules are studied by the Monte Carlo method for small patient horizons and mathematically for large patient horizons. They are shown to be about equally effective and asymptotically optimal from both Bayesian and frequentist points of view and are markedly superior to any fixed sample size procedure.Entities:
Year: 1980 PMID： 16592839 PMCID： PMC349568 DOI： 10.1073/pnas.77.6.3135
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205