Literature DB >> 16591927

Conformation of cyclolinopeptide a observed by circular dichroism.

F Naider1, E Benedetti, M Goodman.   

Abstract

A stereochemical investigation, by circular dichroism, of a synthetic nonapeptide (cyclolinopeptide A) in several organic and organic-sulfuric acid solvents is presented. From this examination, and results found for a conformationally rigid model compound, 1,7,7-trimethyl-3-azabicyclo [2.2.1] heptan-2-one(camphorolactam), it is concluded that cyclolinopeptide A may exist in several conformations in solution. None of these conformations is believed to be stabilized by intramolecular hydrogen bonds. Some details on an x-ray analysis of the cyclic nonapeptide are also presented.

Entities:  

Year:  1971        PMID： 16591927      PMCID： PMC389152          DOI： 10.1073/pnas.68.6.1195

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  Approximate treatment of the conformational characteristics of a cyclic nonapeptide, cyclolinopeptide a.

Authors:  A E Tonelli
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

2.  Flexibility of supposed "rigid" molecules: substituted 2,5-piperazinediones (diketopiperazines).

Authors:  E Benedetti; P Corradini; M Goodman; C Pedone
Journal:  Proc Natl Acad Sci U S A       Date:  1969-03       Impact factor: 11.205

3.  Conformational study of gramicidin S using the phthalimide group as nuclear magnetic resonance marker.

Authors:  R Schwyzer; U Ludescher
Journal:  Biochemistry       Date:  1968-07       Impact factor: 3.162

4.  Location of proline derivatives in conformational space. II. Theoretical optical activity.

Authors:  V Madison; J Schellman
Journal:  Biopolymers       Date:  1970       Impact factor: 2.505

5.  Conformational aspects of polypeptide structure. XXX. Rotatory properties of cyclic and bicyclic amides. Restricted and rigid model compounds for peptide chromophores.

Authors:  M Goodman; C Toniolo; J Falcetta
Journal:  J Am Chem Soc       Date:  1969-03-26       Impact factor: 15.419

6.  Conformations of cyclic peptides. II. Side-chain conformation and ring shape in cyclic dipeptides.

Authors:  K D Kopple; M Ohnishi
Journal:  J Am Chem Soc       Date:  1969-02-12       Impact factor: 15.419

7.  A conformational analysis of gramicidin S-A by nuclear magnetic resonance.

Authors:  A Stern; W A Gibbons; L C Craig
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

8.  Conformation of cyclolinopeptide a observed by nuclear magnetic resonance spectroscopy.

Authors:  A I Brewster; F A Bovey
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

9.  [Investigations on the conformation of the cyclic hexapeptide cyclo-glycyl-L-prolyl-glycyl-glycyl-L-prolyl-glycyl by means of proton magnetic resonance and parallel studies on the cyclodecapeptide gramacidin S].

Authors:  R Schwyzer; U Ludescher
Journal:  Helv Chim Acta       Date:  1969       Impact factor: 2.164
  9 in total
  1 in total

1.  Conformation of cyclolinopeptide a observed by nuclear magnetic resonance spectroscopy.

Authors:  A I Brewster; F A Bovey
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205
  1 in total

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