Literature DB >> 165898

Morphological changes in cultured mammalian cells: prevention by the calcium ionophore A23187.

R C Henneberry, P H Fishman, E Freese.   

Abstract

The morphological changes induced by butyrate in HeLa cells and by monobutyryl or dibutyryl cAMP in CHO cells are prevented by micromolar concentrations of the divalent cation ionophore A23187. The ionophore is unable to prevent such changes in medium from which calcium is omitted. At slightly higher (but nontoxic) concentrations, the ionophore inhibits the butyrate-mediated induction of the ganglioside biosynthetic enzyme, sialyltransferase, in HeLa. In CHO, sialyltransferase activity is normally high and not altered by any of the compounds tested.

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Year:  1975        PMID： 165898     DOI： 10.1016/0092-8674(75)90085-9

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  9 in total

1.  Explantation of mesangial cell 'hillocks': a method for obtaining human mesangial cells in culture.

Authors:  E W Muller; Y Kim; A F Michael; R L Vernier; G K van der Hem; F J van der Woude
Journal:  Int J Exp Pathol       Date:  1992-02       Impact factor: 1.925

2.  Mechanism of action of cholera toxin: effect of receptor density and multivalent binding on activation of adenylate cyclase.

Authors:  P H Fishman; E E Atikkan
Journal:  J Membr Biol       Date:  1980       Impact factor: 1.843

3.  Cyclic AMP accumulation in HeLa cells induced by cholera toxin. Involvement of the ceramide moiety of GM1 ganglioside.

Authors:  M Masserini; P Palestini; M Pitto; V Chigorno; M Tomasi; G Tettamanti
Journal:  Biochem J       Date:  1990-10-01       Impact factor: 3.857

4.  Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen.

Authors:  H K Kleinman; G R Martin; P H Fishman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

5.  Control of growth by picolinic acid: differential response of normal and transformed cells.

Authors:  J A Fernandez-Pol; V H Bono; G S Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

6.  Induction of functional beta-adrenergic receptors in HeLa cells.

Authors:  J F Tallman; C C Smith; R C Henneberry
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

7.  Sodium butyrate induced alterations in lysosomal enzyme activity.

Authors:  R E Kelly
Journal:  In Vitro Cell Dev Biol       Date:  1985-07

8.  Fibrillar organization of fibronectin is expressed coordinately with cell surface gangliosides in a variant murine fibroblast.

Authors:  S Spiegel; K M Yamada; B E Hom; J Moss; P H Fishman
Journal:  J Cell Biol       Date:  1986-05       Impact factor: 10.539

9.  Cyclic AMP-induced morphological transformation of cells infected by temperature-sensitive mouse sarcoma virus. Expression of transformation-associated markers.

Authors:  K D Somers; A D Weberg; S Steiner
Journal:  J Cell Biol       Date:  1977-09       Impact factor: 10.539
  9 in total

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