Literature DB >> 1658938

Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats.

D L Guberski1, V A Thomas, W R Shek, A A Like, E S Handler, A A Rossini, J E Wallace, R M Welsh.   

Abstract

Type I diabetes mellitus is an autoimmune disease resulting from the interaction of genetic and environmental factors. A virus that was identified serologically as Kilham's rat virus (KRV) was isolated from a spontaneously diabetic rat and reproducibly induced diabetes in naive diabetes-resistant (DR) BB/Wor rats. Viral antigen was not identified in pancreatic islet cells, and beta cell cytolysis was not observed until after the appearance of lymphocytic insulitis. KRV did not induce diabetes in major histocompatibility complex-concordant and discordant non-BB rats and did not accelerate diabetes in diabetes-prone BB/Wor rats unless the rats had been reconstituted with DR spleen cells. This model of diabetes may provide insight regarding the interaction of viruses and autoimmune disease [corrected]

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Year:  1991        PMID： 1658938     DOI： 10.1126/science.1658938

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  46 in total

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