Literature DB >> 1658930

Dependence of kidney morphogenesis on the expression of nerve growth factor receptor.

H Sariola1, M Saarma, K Sainio, U Arumäe, J Palgi, A Vaahtokari, I Thesleff, A Karavanov.   

Abstract

Nerve growth factor receptor (NGFR) serves as the binding site for the neurotrophic growth factors. Although NGFR has been found in several embryonic tissues outside the nervous system, the function of NGFR in embryogenesis of non-neuronal organs remains unknown. NGFR is transiently synthesized by embryonic rat kidney and disappears from nephrons upon their terminal differentiation. Anti-sense oligonucleotide inhibition of NGFR expression inhibits kidney morphogenesis. Therefore, NGFR is required not only for development of the nervous system, but also for differentiation of the kidney tubules.

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Year:  1991        PMID: 1658930     DOI: 10.1126/science.1658930

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  39 in total

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7.  Neurotrophin 3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney.

Authors:  A Karavanov; K Sainio; J Palgi; M Saarma; L Saxen; H Sariola
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

8.  Basic fibroblast growth factor can mediate the early inductive events in renal development.

Authors:  A O Perantoni; L F Dove; I Karavanova
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

9.  Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.

Authors:  J L Herrmann; D G Menter; J Hamada; D Marchetti; M Nakajima; G L Nicolson
Journal:  Mol Biol Cell       Date:  1993-11       Impact factor: 4.138

10.  Ovarian innervation develops before initiation of folliculogenesis in the rat.

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