| Literature DB >> 16585018 |
Ellen van der Spek1, Andries C Bloem, Niels W C J van de Donk, Lijnie H Bogers, René van der Griend, Mark H Kramer, Okke de Weerdt, Shulamiet Wittebol, Henk M Lokhorst.
Abstract
In vitro statins induce apoptosis in myeloma and lymphoma cells in a dose-and time-dependent way. In combination with dexamethasone and doxorubicin, statins have a chemo-sensitizing effect. Twenty-eight patients with relapsed myeloma or lymphoma were treated with a dose-escalating regimen of simvastatin for 7 days followed by VAD in myeloma patients and CHOP in lymphoma patients. The maximum tolerated dose was 15 mg/kg/day simvastatin. The most frequently reported side-effects were fatigue, gastrointestinal CTC grade 1-2 and neutropenic fever. The dose-limiting toxicity was neutropenic sepsis and grade 3 gastrointestinal side effects. High-dose simvastatin given immediately prior to chemotherapy is safe and tolerable up to a dose of 15 mg/kg/day.Entities:
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Year: 2006 PMID： 16585018
Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941