Literature DB >> 16584982

The value of immunohistochemical research on PCNA, p53 and heat shock proteins in prostate cancer management: a review.

F Cappello1, A Ribbene, C Campanella, A M Czarnecka, R Anzalone, F Bucchieri, A Palma, G Zummo.   

Abstract

This review addresses the significance of the expression of proliferating cell nuclear antigen (PCNA), p53 and some heat shock proteins (Hsps) in prostate carcinoma (PC). In fact, PCNA and p53 are two widely discussed tools in PC diagnosis, mainly because of the controversy regarding the significance of their expression during prostate cancer development and progression. At the same time, only few studies have shown the potential role of Hsps in carcinogenesis and their overexpression in pre-neoplastic and neoplastic lesions of the prostate. We briefly describe the physiological roles of Hsps in normal cells, and the significance of their immunohistochemical detection in PC as well as in pre-cancerous lesions of the prostate. We will also discuss the possible functional interactions of these molecules in both dysplastic and neoplastic cells.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16584982

Source DB:  PubMed          Journal:  Eur J Histochem        ISSN： 1121-760X            Impact factor:   3.188


  8 in total

1.  Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.

Authors:  Zongqing Tan; Matthew Wortman; Kelsey L Dillehay; William L Seibel; Chris R Evelyn; Shanna J Smith; Linda H Malkas; Yi Zheng; Shan Lu; Zhongyun Dong
Journal:  Mol Pharmacol       Date:  2012-03-07       Impact factor: 4.436

Review 2.  NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.

Authors:  Angela N Flores; Niamh McDermott; Armelle Meunier; Laure Marignol
Journal:  Nat Rev Urol       Date:  2014-08-19       Impact factor: 14.432

3.  Relationship between VEGF and p53 expression and tumor cell proliferation in human gastrointestinal carcinomas.

Authors:  Elvira Montero; Carmen Abreu; Paola Tonino
Journal:  J Cancer Res Clin Oncol       Date:  2007-07-17       Impact factor: 4.553

4.  Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.

Authors:  F Rappa; E Unti; P Baiamonte; F Cappello; N Scibetta
Journal:  Eur J Histochem       Date:  2013-06-28       Impact factor: 3.188

5.  IgG silencing induces apoptosis and suppresses proliferation, migration and invasion in LNCaP prostate cancer cells.

Authors:  Yawen Xu; Binshen Chen; Shaobo Zheng; Yong Wen; Abai Xu; Kai Xu; Bingkun Li; Chunxiao Liu
Journal:  Cell Mol Biol Lett       Date:  2016-12-03       Impact factor: 5.787

6.  Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells.

Authors:  Shan Lu; Zhongyun Dong
Journal:  PLoS One       Date:  2019-10-10       Impact factor: 3.240

7.  Effects of oxygen on the antigenic landscape of prostate cancer cells.

Authors:  Tangeng Ma; Claire A Schreiber; Gaylord J Knutson; Abdelouahid El Khattouti; Marcelo J Sakiyama; Mohamed Hassan; Mary Christine Charlesworth; Benjamin J Madden; Xinchun Zhou; Stanimir Vuk-Pavlović; Christian R Gomez
Journal:  BMC Res Notes       Date:  2015-11-18

8.  2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90.

Authors:  Anna Kamm; Paulina Przychodzeń; Alicja Kuban-Jankowska; Antonella Marino Gammazza; Francesco Cappello; Agnieszka Daca; Michał A Żmijewski; Michał Woźniak; Magdalena Górska-Ponikowska
Journal:  J Oncol       Date:  2019-10-02       Impact factor: 4.375
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.