| Literature DB >> 16584783 |
Marta Stanzani1, Nicola Vianelli, Giuseppe Bandini, Stefania Paolini, Mario Arpinati, Francesca Bonifazi, Benedetta Giannini, Claudio Agostinelli, Michele Baccarani, Paolo Ricci.
Abstract
Fusarium is an opportunistic fungal pathogen which is emerging as a significant cause of morbidity and mortality in the immunocompromised host [Fleming RV, Walsh TJ, Anaissie EJ. Emerging and less common fungal pathogens. Infect Dis Clin North Am 2002;16:915-34]. This disease can be localized, focally invasive or disseminated, when two or more noncontiguous sites are involved. Therapeutic options are scarce and mortality reaches 80-90% in patients subjected to allogeneic hematopoietic stem cell transplant (allo-SCT) [Nucci M, Marr KA, Queiroz-Telles F, Martins CA, Trabasso P, Costa S, et al. Fusarium infection in hematopoietic stem cell transplant recipient. Clin Infect Dis 2004;1237-42]. We report a case of disseminated Fusariosis in a severe immunocompromised patient after allo-SCT that responded to treatment with the early combination of intravenous voriconazole and liposomal amphotericin B.Entities:
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Year: 2006 PMID： 16584783 DOI： 10.1016/j.jinf.2006.02.011
Source DB: PubMed Journal: J Infect ISSN： 0163-4453 Impact factor: 6.072