Literature DB >> 165847

Tetramethylenedisulphotetramine: an inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat.

N G Bowery, D A Brown, J F Collins.   

Abstract

Tetramethylenedisulphotetramine (TETS), a potent convulsant, antagonized the depolarizing action gamma-aminobutyric acid (GABA) in the isolated superior cervical ganglion of the rat. No antagonism of responses to the cholinomimetic agent carbachol was observed. TETS appeared to act in a non-competitive manner and was reversible. Its activity profile was comparable to that of bicuculline in the same tissue except that the latter appears to act in a competitive manner.

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Year:  1975        PMID： 165847      PMCID： PMC1666460          DOI： 10.1111/j.1476-5381.1975.tb07379.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Reduction of tetramine toxicity by sedatives and anticonvulsants.

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Journal:  J Pharm Sci       Date:  1961-10       Impact factor: 3.534

2.  Autoradiographic localization of sites of (3H)gamma-aminobutyric acid accumulation in peripheral autonomic ganglia.

Authors:  J A Young; D A Brown; J S Kelly; F Schon
Journal:  Brain Res       Date:  1973-12-07       Impact factor: 3.252

3.  The actions of gamma-aminobutyric acid and related amino acids on mammalian autonomic ganglia.

Authors:  W C de Groat
Journal:  J Pharmacol Exp Ther       Date:  1970-04       Impact factor: 4.030

4.  -Aminobutyric acid uptake by sympathetic ganglia.

Authors:  N G Bowery; D A Brown
Journal:  Nat New Biol       Date:  1972-07-19

5.  Bicuculline methochloride as a GABA antagonist.

Authors:  G A Johnston; P M Beart; D R Curtis; C J Game; R M McCulloch; R M Maclachlan
Journal:  Nat New Biol       Date:  1972-12-13

6.  Action of -aminobutyric acid (GABA) on rat sympathetic ganglion cells.

Authors:  P R Adams; D A Brown
Journal:  Br J Pharmacol       Date:  1973-03       Impact factor: 8.739

7.  The effects of bicuculline and GABA on the superior cervical ganglion of the cat.

Authors:  W C DeGroat; P M Lalley; M Block
Journal:  Brain Res       Date:  1971-02-05       Impact factor: 3.252

Review 8.  Amino acid transmitters in the mammalian central nervous system.

Authors:  D R Curtis; G A Johnston
Journal:  Ergeb Physiol       Date:  1974

9.  Depolarizing actions of gamma-aminobutyric acid and related compounds on rat superior cervical ganglia in vitro.

Authors:  N G Bowery; D A Brown
Journal:  Br J Pharmacol       Date:  1974-02       Impact factor: 8.739
  9 in total
  16 in total

1.  Effect of tetramethylenedisulphotetramine on the membrane conductance increase produced by gamma-amino-butyric acid at the crab neuromuscular junction.

Authors:  W A Large
Journal:  Br J Pharmacol       Date:  1975-04       Impact factor: 8.739

2.  Reversal of the action of amino acid antagonists by barbiturates and other hypnotic drugs.

Authors:  N G Bowery; A Dray
Journal:  Br J Pharmacol       Date:  1978-05       Impact factor: 8.739

Review 3.  GABAA receptor: Positive and negative allosteric modulators.

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Journal:  Neuropharmacology       Date:  2018-01-31       Impact factor: 5.250

Review 4.  Tetramethylenedisulfotetramine neurotoxicity: What have we learned in the past 70 years?

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5.  The depolarization of feline ventral horn group Ia spinal afferent terminations by GABA.

Authors:  D R Curtis; D Lodge
Journal:  Exp Brain Res       Date:  1982       Impact factor: 1.972

6.  The antidotal effects of high-dosage gamma-aminobutyric acid on acute tetramine poisoning as compared with sodium dimercaptopropane sulfonate.

Authors:  Peng Sun; Jiyuan Han; Yuying Weng
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2007-08

Review 7.  Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.

Authors:  Isaac N Pessah; Michael A Rogawski; Daniel J Tancredi; Heike Wulff; Dorota Zolkowska; Donald A Bruun; Bruce D Hammock; Pamela J Lein
Journal:  Ann N Y Acad Sci       Date:  2016-07-28       Impact factor: 5.691

8.  Behavioral intoxication following voluntary oral ingestion of tetramethylenedisulfotetramine: Dose-dependent onset, severity, survival, and recovery.

Authors:  Nathaniel C Rice; Noah A Rauscher; Jeffrey L Langston; Todd M Myers
Journal:  Neurotoxicology       Date:  2017-09-07       Impact factor: 4.294

9.  Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.

Authors:  Zhengyu Cao; Bruce D Hammock; Mark McCoy; Michael A Rogawski; Pamela J Lein; Isaac N Pessah
Journal:  Toxicol Sci       Date:  2012-08-13       Impact factor: 4.849

10.  Indirect effects of amino-acids on sympathetic ganglion cells mediated through the release of gamma-aminobutyric acid from glial cells.

Authors:  N G Bowery; D A Brown; G G Collins; M Galvan; S Marsh; G Yamini
Journal:  Br J Pharmacol       Date:  1976-05       Impact factor: 8.739
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