Literature DB >> 16584141

Quantitative measurement of indomethacin crystallinity in indomethacin-silica gel binary system using differential scanning calorimetry and X-ray powder diffractometry.

Xiaohong Pan1, Thomas Julian, Larry Augsburger.   

Abstract

Differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD) methods were developed for the quantitative analysis of the crystallinity of indomethacin (IMC) in IMC and silica gel (SG) binary system. The DSC calibration curve exhibited better linearity than that of XRPD. No phase transformation occurred in the IMC-SG mixtures during DSC measurement. The major sources of error in DSC measurements were inhomogeneous mixing and sampling. Analyzing the amount of IMC in the mixtures using high-performance liquid chromatography (HPLC) could reduce the sampling error. DSC demonstrated greater sensitivity and had less variation in measurement than XRPD in quantifying crystalline IMC in the IMC-SG binary system.

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Year:  2006        PMID： 16584141      PMCID： PMC2750718          DOI： 10.1208/pt070111

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN： 1530-9932            Impact factor:   3.246


  17 in total

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Journal:  Chem Pharm Bull (Tokyo)       Date:  1988-10       Impact factor: 1.645

5.  Physical and chemical changes of medicinals in mixtures with adsorbents in the solid state. II. Application of reduced pressure treatment for the improvement of dissolution of flufenamic acid.

Authors:  T Konno; K Kinuno
Journal:  Chem Pharm Bull (Tokyo)       Date:  1989-09       Impact factor: 1.645

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Authors:  S M Alsaidan; A A Alsughayer; A G Eshra
Journal:  Drug Dev Ind Pharm       Date:  1998-04       Impact factor: 3.225

9.  Inhibition of indomethacin crystallization in poly(vinylpyrrolidone) coprecipitates.

Authors:  M Yoshioka; B C Hancock; G Zografi
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Authors:  A Park; L G Cima
Journal:  J Biomed Mater Res       Date:  1996-05
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Journal:  AAPS PharmSciTech       Date:  2013-06-13       Impact factor: 3.246

5.  Effects of polymer type and storage relative humidity on the kinetics of felodipine crystallization from amorphous solid dispersions.

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Journal:  Pharm Res       Date:  2009-10-06       Impact factor: 4.200

6.  Improvement of Physico-mechanical Properties of Partially Amorphous Acetaminophen Developed from Hydroalcoholic Solution Using Spray Drying Technique.

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  6 in total

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