Literature DB >> 1658327

Interleukin-6 and retroperitoneal fibromatosis from SRV-2-infected macaques with simian AIDS.

S T Roodman1, M D Woon, J W Hoffmann, P Theodorakis, C C Tsai, H N Wu, C C Tsai.   

Abstract

We investigated the role of Interleukin-6 (IL-6) as an autocrine growth factor for the retroperitoneal fibromatosis (RF) cells present in macaques infected with the simian retrovirus type 2 (SRV-2). Elevated levels of IL-6 were found in serum of SRV-2 antibody-positive macaques, ascites from RF-positive animals, and RF cell line culture media. IL-6 mRNA levels increased approximately five-fold in RF cells incubated with exogenous SRV-2. In RF cells, SRV-2 functions to increase IL-6 mRNA and protein production and presumably serves as autocrine growth factor.

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Year:  1991        PMID： 1658327

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  3 in total

1.  Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species.

Authors:  T M Rose; K B Strand; E R Schultz; G Schaefer; G W Rankin; M E Thouless; C C Tsai; M L Bosch
Journal:  J Virol       Date:  1997-05       Impact factor: 5.103

2.  Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD).

Authors:  B U Orzechowska; M Manoharan; J Sprague; R D Estep; M K Axthelm; S W Wong
Journal:  J Med Primatol       Date:  2009-10       Impact factor: 0.667

3.  Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma: animal model for KSHV-associated malignancies.

Authors:  Beata U Orzechowska; Michael F Powers; Jerald Sprague; He Li; Bonnie Yen; Robert P Searles; Michael K Axthelm; Scott W Wong
Journal:  Blood       Date:  2008-08-29       Impact factor: 22.113
  3 in total

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