| Literature DB >> 16582909 |
Susan Service1, Joseph DeYoung, Maria Karayiorgou, J Louw Roos, Herman Pretorious, Gabriel Bedoya, Jorge Ospina, Andres Ruiz-Linares, António Macedo, Joana Almeida Palha, Peter Heutink, Yurii Aulchenko, Ben Oostra, Cornelia van Duijn, Marjo-Riitta Jarvelin, Teppo Varilo, Lynette Peddle, Proton Rahman, Giovanna Piras, Maria Monne, Sarah Murray, Luana Galver, Leena Peltonen, Chiara Sabatti, Andrew Collins, Nelson Freimer.
Abstract
The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.Mesh：
Year: 2006 PMID： 16582909 DOI： 10.1038/ng1770
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330