Literature DB >> 16581968

Is the Rac GTPase-activating toxin CNF1 a smart hijacker of host cell fate?

Walter Malorni1, Carla Fiorentini.   

Abstract

The term mitotic catastrophe (MC) was coined to describe the mammalian cell death caused by aberrant mitosis. MC occurs with features that are fundamentally different from those typifying other forms of cell death, including apoptosis. We report here for the first time that the Rac-activating toxin CNF1 interferes with the occurrence of MC and leads to aneuploidy and multinucleation. This seems to be in line with the anti-apoptotic activity of the toxin and consistent with the hypothesis that points at CNF1 as a toxin bearing a carcinogenic potential.

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Year:  2006        PMID： 16581968     DOI： 10.1096/fj.05-4706hyp

Source DB:  PubMed          Journal:  FASEB J        ISSN： 0892-6638            Impact factor:   5.191


  14 in total

Review 1.  CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.

Authors:  Mengfei Ho; Amel Mettouchi; Brenda A Wilson; Emmanuel Lemichez
Journal:  Pathog Dis       Date:  2018-07-01       Impact factor: 3.166

Review 2.  Bacterial protein toxins that modify host regulatory GTPases.

Authors:  Klaus Aktories
Journal:  Nat Rev Microbiol       Date:  2011-06-16       Impact factor: 60.633

Review 3.  Different types of cell death induced by enterotoxins.

Authors:  Chiou-Feng Lin; Chia-Ling Chen; Wei-Ching Huang; Yi-Lin Cheng; Chia-Yuan Hsieh; Chi-Yun Wang; Ming-Yuan Hong
Journal:  Toxins (Basel)       Date:  2010-08-11       Impact factor: 4.546

Review 4.  Cytotoxic Necrotizing Factors (CNFs)-A Growing Toxin Family.

Authors:  Zeynep Knust; Gudula Schmidt
Journal:  Toxins (Basel)       Date:  2011-04-08       Impact factor: 4.546

5.  The Rho-activating CNF1 toxin from pathogenic E. coli: a risk factor for human cancer development?

Authors:  Sara Travaglione; Alessia Fabbri; Carla Fiorentini
Journal:  Infect Agent Cancer       Date:  2008-03-12       Impact factor: 2.965

Review 6.  The cytotoxic necrotizing factor 1 from E. coli: a janus toxin playing with cancer regulators.

Authors:  Alessia Fabbri; Sara Travaglione; Giulia Ballan; Stefano Loizzo; Carla Fiorentini
Journal:  Toxins (Basel)       Date:  2013-08-14       Impact factor: 4.546

Review 7.  Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.

Authors:  Rachid A El-Aouar Filho; Aurélie Nicolas; Thiago L De Paula Castro; Martine Deplanche; Vasco A De Carvalho Azevedo; Pierre L Goossens; Frédéric Taieb; Gerard Lina; Yves Le Loir; Nadia Berkova
Journal:  Front Cell Infect Microbiol       Date:  2017-05-23       Impact factor: 5.293

8.  Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli.

Authors:  Zhen Zhang; Kyaw Min Aung; Bernt Eric Uhlin; Sun Nyunt Wai
Journal:  Sci Rep       Date:  2018-12-12       Impact factor: 4.379

Review 9.  Potential Use of Biotherapeutic Bacteria to Target Colorectal Cancer-Associated Taxa.

Authors:  Garreth W Lawrence; Máire Begley; Paul D Cotter; Caitriona M Guinane
Journal:  Int J Mol Sci       Date:  2020-01-30       Impact factor: 5.923

10.  High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer.

Authors:  Emmanuel Buc; Damien Dubois; Pierre Sauvanet; Jennifer Raisch; Julien Delmas; Arlette Darfeuille-Michaud; Denis Pezet; Richard Bonnet
Journal:  PLoS One       Date:  2013-02-14       Impact factor: 3.240
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