| Literature DB >> 16581216 |
Guilherme Ehrenbrink1, Fernanda Schäfer Hakenhaar, Tiago Boeira Salomon, Antonella Pilla Petrucci, Marcia Rodrigues Sandri, Mara Silveira Benfato.
Abstract
The theory of free radicals and accumulation of damages suggests that the reactive species of oxygen play a key role in the context of aging. Thus, for the best understanding of the aging process, the study of antioxidant defenses has to be considered as part of gerontology. The present work evaluated the enzymatic activity of the enzymes catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), and measured the amount of oxidative damage in proteins (carbonyl groups) in brains of rats of both sexes in the ages of 3-, 6-, 12- and 20-months. The results suggest that the patterns of activity and accumulation of damages can be sex-specific and related to the cycle of reproductive life of the organism.Entities:
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Year: 2006 PMID： 16581216 DOI： 10.1016/j.exger.2006.02.007
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032