| Literature DB >> 16581163 |
Nadav Orr1, Eyal Klement, David Gillis, Tamar Sela, Raid Kayouf, Estela Derazne, Itamar Grotto, Ran Balicer, Michael Huerta, Lisa Aviram, Ruhama Ambar, Yoram Epstein, Yuval Heled, Dani Cohen.
Abstract
We evaluated in a prospective study the immune response of naïve subjects to a single dose of inactivated Hepatitis A vaccine. Ninety-seven percent of the vaccinees sero-converted 1 month after vaccination and 93% were still positive 2 years later. All of the vaccinees had a strong booster response 2 years after the single dose. Avaxim was more immunogenic than Vaqta for the primary dose (p = 0.01 for sero-positivity, p<0.001 for antibody level) but no differences were found after boosting with Avaxim. Performance of intense physical activity during the first month after a single vaccine dose was associated with lower antibody levels (p = 0.004). This study indicates that a single dose of inactivated HAV vaccine elicits protective immune memory for at least 2 years.Entities:
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Year: 2006 PMID： 16581163 DOI： 10.1016/j.vaccine.2006.03.010
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641