| Literature DB >> 16580654 |
Melli Mahmoudi1, John Mercer, Martin Bennett.
Abstract
There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage.Entities:
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Year: 2006 PMID： 16580654 DOI： 10.1016/j.cardiores.2006.03.002
Source DB: PubMed Journal: Cardiovasc Res ISSN： 0008-6363 Impact factor: 10.787