Literature DB >> 16580650

Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse.

Friederike Kienzler1, Peter Jedlicka, Mario Vuksic, Thomas Deller, Stephan W Schwarzacher.   

Abstract

Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefore, this mouse model of seizure-induced hippocampal injury can be used for a wide variety of studies in genetically altered conditions not available in rats.

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Year:  2006        PMID： 16580650     DOI： 10.1016/j.brainres.2006.02.055

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

1.  Long-term intermittent high-amplitude subcutaneous nerve stimulation reduces sympathetic tone in ambulatory dogs.

Authors:  Yuan Yuan; Zhaolei Jiang; Ye Zhao; Wei-Chung Tsai; Jheel Patel; Lan S Chen; Changyu Shen; Shien-Fong Lin; Huei-Sheng Vincent Chen; Thomas H Everett; Michael C Fishbein; Zhenhui Chen; Peng-Sheng Chen
Journal:  Heart Rhythm       Date:  2017-11-27       Impact factor: 6.343

2.  Antiarrhythmic effects of stimulating the left dorsal branch of the thoracic nerve in a canine model of paroxysmal atrial tachyarrhythmias.

Authors:  Ye Zhao; Yuan Yuan; Wei-Chung Tsai; Zhaolei Jiang; Zhi-Peng Tian; Changyu Shen; Shien-Fong Lin; Michael C Fishbein; Thomas H Everett; Zhenhui Chen; Peng-Sheng Chen
Journal:  Heart Rhythm       Date:  2018-04-11       Impact factor: 6.343

3.  Direct visualization of the perforant pathway in the human brain with ex vivo diffusion tensor imaging.

Authors:  Jean C Augustinack; Karl Helmer; Kristen E Huber; Sita Kakunoori; Lilla Zöllei; Bruce Fischl
Journal:  Front Hum Neurosci       Date:  2010-05-28       Impact factor: 3.169

4.  Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation-induced status epilepticus in the mouse.

Authors:  Friederike Kienzler; Braxton A Norwood; Robert S Sloviter
Journal:  J Comp Neurol       Date:  2009-07-10       Impact factor: 3.215

5.  Crossed Entorhino-Dentate Projections Form and Terminate With Correct Layer-Specificity in Organotypic Slice Cultures of the Mouse Hippocampus.

Authors:  Lars Hildebrandt-Einfeldt; Kenrick Yap; Mandy H Paul; Carolin Stoffer; Nadine Zahn; Alexander Drakew; Maximilian Lenz; Andreas Vlachos; Thomas Deller
Journal:  Front Neuroanat       Date:  2021-02-11       Impact factor: 3.856

6.  Re-innervation of the Denervated Dentate Gyrus by Sprouting Associational and Commissural Mossy Cell Axons in Organotypic Tissue Cultures of Entorhinal Cortex and Hippocampus.

Authors:  Domenico Del Turco; Mandy H Paul; Viktor J Beeg Moreno; Lars Hildebrandt-Einfeldt; Thomas Deller
Journal:  Front Mol Neurosci       Date:  2019-11-12       Impact factor: 5.639
  6 in total

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