Literature DB >> 16580331

Usefulness of preoperative lymphoscintigraphy in patients who undergo radical hysterectomy and pelvic lymphadenectomy for cervical cancer.

Michael Frumovitz1, Robert L Coleman, Isis W Gayed, Pedro T Ramirez, Judith K Wolf, David M Gershenson, Charles F Levenback.   

Abstract

OBJECTIVE: The purpose of this study was to assess the value of preoperative lymphoscintigraphy before intraoperative lymphatic mapping for sentinel lymph node identification during radical hysterectomy. STUDY
DESIGN: Fifty patients underwent intraoperative lymphatic mapping on our institutional review board-approved protocol. The location of sentinel lymph nodes that were found on lymphoscintigraphy and intraoperative lymphatic mapping were compared.
RESULTS: Fifteen of 21 patients (71%) with solitary sentinel lymph nodes that were found on lymphoscintigraphy had multiple sentinel lymph node basins found during the operation. Thirteen of 25 patients (52%) with unilateral sentinel lymph node basins that were found on lymphoscintigraphy had bilateral sentinel lymph nodes at intraoperative lymphatic mapping. Of 15 patients with 2 sentinel lymph node locations that were identified on lymphoscintigraphy, 12 patients (80%) had > or = 3 found during the operation. Of the sentinel lymph nodes that were located on the external iliac basin (n = 47) on lymphoscintigraphy, only 20 lymph nodes (43%) were found at that location during the operation. Concordance between the 2 methods was poor. Seven of the 9 patients with lymph node metastases had disease that was limited to the sentinel lymph nodes.
CONCLUSION: Preoperative lymphoscintigraphy adds little value over intraoperative lymphatic mapping for sentinel lymph node identification during radical hysterectomy.

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Year:  2006        PMID: 16580331     DOI: 10.1016/j.ajog.2005.12.018

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN: 0002-9378            Impact factor:   8.661


  5 in total

Review 1.  Up-to-date management of lymph node metastasis and the role of tailored lymphadenectomy in cervical cancer.

Authors:  Noriaki Sakuragi
Journal:  Int J Clin Oncol       Date:  2007-06-27       Impact factor: 3.402

Review 2.  Sentinel lymph node evaluation in women with cervical cancer.

Authors:  Laura L Holman; Charles F Levenback; Michael Frumovitz
Journal:  J Minim Invasive Gynecol       Date:  2014-01-07       Impact factor: 4.137

Review 3.  Lymphatic mapping and sentinel node detection in gynecologic malignancies of the lower genital tract.

Authors:  Michael Frumovitz; Pedro T Ramirez; Charles Levenback
Journal:  Curr Oncol Rep       Date:  2005-11       Impact factor: 5.075

4.  Feasibility and performance of lymphoscintigraphy in sentinel lymph node biopsy for early cervical cancer: results of the prospective multicenter SENTICOL study.

Authors:  Anne-Sophie Bats; Albane Frati; Marc Froissart; Isabelle Orliaguet; Denis Querleu; Slimane Zerdoud; Eric Leblanc; Hélène Gauthier; Catherine Uzan; Désirée Deandreis; Emile Darai; Khaldoun Kerrou; Henri Marret; Emilie Lenain; Patrice Mathevet; Fabrice Lecuru
Journal:  Ann Nucl Med       Date:  2014-11-15       Impact factor: 2.668

Review 5.  Ultrastaging of lymph node in uterine cancers.

Authors:  Corinne Bézu; Charles Coutant; Marcos Ballester; Jean-Guillaume Feron; Roman Rouzier; Serge Uzan; Emile Daraï
Journal:  J Exp Clin Cancer Res       Date:  2010-01-21
  5 in total

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