| Literature DB >> 16580203 |
Akira Kawamura1, Angelika Brekman, Yevgeniy Grigoryev, Tal H Hasson, Anna Takaoka, Stephanie Wolfe, Clifford E Soll.
Abstract
A screening methodology called 'genomic screening' was established to identify natural products that can regulate cellular gene expression. Application of genomic screening to Keishi-bukuryo-gan (KBG), a Japanese herbal medicine formulation, identified a previously unnoticed transcriptional effect by linoleic acid, a known KBG component. The approach opens up a possibility to develop cell-permeable molecular tools for functional genomics research and sets a stage to evaluate the potential of natural products for transcription therapies.Entities:
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Year: 2006 PMID： 16580203 DOI： 10.1016/j.bmcl.2006.03.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823