| Literature DB >> 16580199 |
Raymond J Patch1, Christian A Baumann, Jian Liu, Alan C Gibbs, Heidi Ott, Jennifer Lattanze, Mark R Player.
Abstract
A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 microM) and blocks the proliferation of MV4-11 cells (IC50 = 0.41 microM). Structure-activity relationship studies within this series are described in the context of a proposed binding model within the ATP binding site of the enzyme.Entities:
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Year: 2006 PMID： 16580199 DOI： 10.1016/j.bmcl.2006.03.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823