| Literature DB >> 16579992 |
Atsushi Suzuki1, Akihiko Fujii, Naoki Yamamoto, Masaki Yamamoto, Hideo Ohminami, Akiyo Kameyama, Yusuke Shibuya, Yoshinori Nishizawa, Ichiro Tokimitsu, Ikuo Saito.
Abstract
Chlorogenic acid, a polyphenol found in coffee, has antihypertensive actions, but epidemiologic data on the effects of coffee on blood pressure are controversial. Specific coffee components that inhibit the hypotensive effect of chlorogenic acid and the physiologic mechanisms underlying the effects of coffee without these components were investigated. One component, hydroxyhydroquinone (HHQ), inhibited the hypotensive effects of chlorogenic acid in spontaneously hypertensive rats (SHR). The attenuation of hypertension by HHQ-free coffee was associated with nitric oxide, the suppression of mRNA expression of NAD(P)H oxidase, and the improvement in endothelium-dependent vasodilation in the aorta. Thus, HHQ-free coffee might regulate vascular tone by improving the bioavailability of nitric oxide in SHR.Entities:
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Year: 2006 PMID： 16579992 DOI： 10.1016/j.febslet.2006.03.047
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124