The in-vitro activity of temafloxacin compared with other antimicrobial agents.

Temafloxacin, like other 4-quinolones, was highly active against most isolates of Enterobacteriaceae. It was slightly less active than ciprofloxacin but approximately as active as ofloxacin and enoxacin. It was the most active of the quinolones against Acinetobacter spp. and Xanthomonas maltophilia but was slightly less active than ciprofloxacin against Pseudomonas spp. Temafloxacin was highly active against Haemophilus influenzae, Moraxella catarrhalis and Neisseria gonorrhoeae and was the most active of the quinolones against Gardnerella vaginalis and Campylobacter coli/jejuni. It was more active than ciprofloxacin against most staphylococci and equally active against streptococci and enterococci. Temafloxacin was the most active quinolone against anaerobic bacteria and, with the exception of a few isolates of Bacteroides spp. and some clostridia, all anaerobes were within the sensitive range (MIC less than or equal to 2 mg/l).