Literature DB >> 1657847

Ki-ras activation in pancreatic carcinomas of Syrian hamsters induced by N-nitrosobis(2-hydroxypropyl)amine.

T Ushijima1, M Tsutsumi, R Sakai, Y Ishizaka, F Takaku, Y Konishi, M Takahashi, T Sugimura, M Nagao.   

Abstract

Five pancreatic carcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in Syrian golden hamsters were analyzed for activation of Ki-ras at codons 12 and 13, using the polymerase chain reaction and direct sequencing. The Ki-ras gene was shown to be activated in four of the five carcinomas, and the results were further confirmed by subcloning and sequencing. All the mutations involved a G-to-A transition at the second position of codon 12, which resulted in a change at the amino acid level from glycine to aspartic acid. This mutation is identical with that reported for pancreatic tumors of Syrian hamsters induced by N-nitrosobis(2-oxopropyl)amine.

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Year:  1991        PMID： 1657847      PMCID： PMC5918598          DOI： 10.1111/j.1349-7006.1991.tb01928.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


JV‐nitrosobis (2‐oxopropyl) amine AT‐nitrosobis (2‐hydroxypropyl)amine JV‐nitroso (2‐hydroxypropyl) (2‐oxopropyl)amine polymerase chain reaction
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Authors:  N F Gonzalez-Cadavid; D Zhou; H Battifora; M Bar-Eli; M J Cline
Journal:  Oncogene       Date:  1989-09       Impact factor: 9.867

2.  KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.

Authors:  V T Smit; A J Boot; A M Smits; G J Fleuren; C J Cornelisse; J L Bos
Journal:  Nucleic Acids Res       Date:  1988-08-25       Impact factor: 16.971

3.  Activation of K-ras in transplantable pancreatic ductal adenocarcinomas of Syrian golden hamsters.

Authors:  W L Cerny; K A Mangold; D G Scarpelli
Journal:  Carcinogenesis       Date:  1990-11       Impact factor: 4.944

4.  Major urinary metabolites in hamsters and rats treated with N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine.

Authors:  D M Kokkinakis; P F Hollenberg; D G Scarpelli
Journal:  Cancer Res       Date:  1985-08       Impact factor: 12.701

5.  Metabolism of pancreatic carcinogens N-nitroso-2,6-dimethylmorpholine and N-nitrosobis(2-oxopropyl)amine by microsomes and cytosol of hamster pancreas and liver.

Authors:  D M Kokkinakis; D G Scarpelli; M S Rao; P F Hollenberg
Journal:  Cancer Res       Date:  1983-12       Impact factor: 12.701

6.  Long-term persistence of DNA alkylation in hamster tissues after N-nitrosobis(2-oxopropyl)amine.

Authors:  J Bax; P M Pour; D L Nagel; T A Lawson; R A Woutersen; E Scherer
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

Review 7.  Animal models of exocrine pancreatic carcinogenesis.

Authors:  M S Rao
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

8.  High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas.

Authors:  K Grünewald; J Lyons; A Fröhlich; H Feichtinger; R A Weger; G Schwab; J W Janssen; C R Bartram
Journal:  Int J Cancer       Date:  1989-06-15       Impact factor: 7.396

9.  Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers from Japanese patients.

Authors:  M Mariyama; K Kishi; K Nakamura; H Obata; S Nishimura
Journal:  Jpn J Cancer Res       Date:  1989-07

10.  Frequent glycine-to-aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese.

Authors:  Y Nagata; M Abe; K Motoshima; E Nakayama; H Shiku
Journal:  Jpn J Cancer Res       Date:  1990-02
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Authors:  Yewei Liu; Ting Yin; Yuanbo Feng; Marlein Miranda Cona; Gang Huang; Jianjun Liu; Shaoli Song; Yansheng Jiang; Qian Xia; Johannes V Swinnen; Guy Bormans; Uwe Himmelreich; Raymond Oyen; Yicheng Ni
Journal:  Quant Imaging Med Surg       Date:  2015-10

2.  Point mutations of ras genes in human adrenal cortical tumors: absence in adrenocortical hyperplasia.

Authors:  T Yashiro; H Hara; N C Fulton; T Obara; E L Kaplan
Journal:  World J Surg       Date:  1994 Jul-Aug       Impact factor: 3.352

3.  Comparison of K-ras oncogene activation in pancreatic duct carcinomas and cholangiocarcinomas induced in hamsters by N-nitrosobis(2-hydroxypropyl)amine.

Authors:  M Tsutsumi; Y Murakami; S Kondoh; T Tsujiuchi; K Hohnoki; K Horiguchi; O Noguchi; E Kobayashi; S Okita; T Sekiya
Journal:  Jpn J Cancer Res       Date:  1993-09

4.  K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.

Authors:  M Tsutsumi; S Kondoh; O Noguchi; K Horiguchi; E Kobayashi; S Okita; K Ohashi; K Honoki; T Tsujiuchi; Y Konishi
Journal:  Jpn J Cancer Res       Date:  1993-11

5.  Presence of p53 mutations in 3Y1-B clone 1-6: a rat cell line widely used as a normal immortalized fibroblast.

Authors:  T Ushijima; H Makino; M Nakayasu; S Aonuma; M Takeuchi; K Segawa; T Sugimura; M Nagao
Journal:  Jpn J Cancer Res       Date:  1994-05
  5 in total

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