Literature DB >> 1657810

Norepinephrine inhibits human natural killer cell activity in vitro.

T Takamoto1, Y Hori, Y Koga, H Toshima, A Hara, M M Yokoyama.   

Abstract

The effect of norepinephrine on human NK cell activity was investigated using a flow cytometry assay. NK cell activity was found to be inhibited by direct addition of norepinephrine to lymphocyte/target cell mixtures in a dose-dependent fashion. This inhibitory effect of norepinephrine was blocked by propranolol but not by atenolol. The results suggest that norepinephrine has a negative influence on NK cell activity and that the effect of norepinephrine is mediated via beta 2-adrenoceptors.

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Year:  1991        PMID： 1657810     DOI： 10.3109/00207459108987189

Source DB:  PubMed          Journal:  Int J Neurosci        ISSN： 0020-7454            Impact factor:   2.292


  19 in total

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