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Literature DB >> 1657787

Evidence for polymorphonuclear leukocyte collagenase and 92-kilodalton gelatinase in gingival crevicular fluid.

C M Overall¹, J Sodek, C A McCulloch, P Birek.

Abstract

Analysis of inflammatory exudate collected from sites of experimental periodontitis in cynomolgus monkeys has revealed the presence of collagenase and a 92-kDa gelatinase that comigrated after electrophoresis with the 92-kDa gelatinase released from polymorphonuclear leukocytes. Since neutralizing antibodies to fibroblast collagenase had no effect on the collagenase activity and bacterial collagenases could not be detected, polymorphonuclear leukocytes appear to be the major source of collagenolytic proteinases in inflammatory fluid from gingiva.

Entities: Disease Species

Mesh：

Substances：

Year: 1991 PMID： 1657787 PMCID： PMC259099 DOI： 10.1128/iai.59.12.4687-4692.1991

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

45 in total

1. Monocyte procollagenase and tissue inhibitor of metalloproteinases. Identification, characterization, and regulation of secretion.

Authors: E J Campbell; J D Cury; C J Lazarus; H G Welgus
Journal: J Biol Chem Date: 1987-11-25 Impact factor: 5.157

2. Transforming growth factor-beta regulation of collagenase, 72 kDa-progelatinase, TIMP and PAI-1 expression in rat bone cell populations and human fibroblasts.

Authors: C M Overall; J L Wrana; J Sodek
Journal: Connect Tissue Res Date: 1989 Impact factor: 3.417

3. Initial characterization of a neutral metalloproteinase, active on native 3/4-collagen fragments, synthesized by ROS 17/2.8 osteoblastic cells, periodontal fibroblasts, and identified in gingival crevicular fluid.

Authors: C M Overall; J Sodek
Journal: J Dent Res Date: 1987-07 Impact factor: 6.116

4. Identification and characterization of enamel proteinases isolated from developing enamel. Amelogeninolytic serine proteinases are associated with enamel maturation in pig.

Authors: C M Overall; H Limeback
Journal: Biochem J Date: 1988-12-15 Impact factor: 3.857

5. H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

Authors: I E Collier; S M Wilhelm; A Z Eisen; B L Marmer; G A Grant; J L Seltzer; A Kronberger; C S He; E A Bauer; G I Goldberg
Journal: J Biol Chem Date: 1988-05-15 Impact factor: 5.157

6. Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: correlation with periodontal disease activity in adult and juvenile periodontitis.

Authors: S Gangbar; C M Overall; C A McCulloch; J Sodek
Journal: J Periodontal Res Date: 1990-09 Impact factor: 4.419

7. Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

Authors: C M Overall; J Sodek
Journal: J Biol Chem Date: 1990-12-05 Impact factor: 5.157

8. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.

Authors: S M Wilhelm; I E Collier; B L Marmer; A Z Eisen; G A Grant; G I Goldberg
Journal: J Biol Chem Date: 1989-10-15 Impact factor: 5.157

9. Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: evidence that breakdown is mediated by metalloproteinases.

Authors: M C Meikle; S J Atkinson; R V Ward; G Murphy; J J Reynolds
Journal: J Periodontal Res Date: 1989-05 Impact factor: 4.419

10. Gelatinase (type IV collagenase) immunolocalization in cells and tissues: use of an antiserum to rabbit bone gelatinase that identifies high and low Mr forms.

Authors: G Murphy; R M Hembry; A M McGarrity; J J Reynolds; B Henderson
Journal: J Cell Sci Date: 1989-03 Impact factor: 5.285

3 in total