Literature DB >> 1657688

Do H3-receptors participate in the effects of histamine on electrically-evoked contractions of rat vas deferens?

P Vassilev1, D Staneva-Stoytcheva, V Mutafova-Yambolieva.   

Abstract

1. The specific effects of histamine were studied on rat vas deferens contractions induced by electrical field stimulation (0.1 Hz, 1 pulse, 1 msec duration, supramaximal voltage). 2. Histamine (5 x 10(-7)-10(-4) M) inhibited the electrically-evoked contractions (EEC). This effect was unchanged after the H1-receptor antagonist diphenhydramine (5 x 10(-6) M) and was decreased after the H2-receptor antagonist cimetidine (10(-5) M). 3. Betahistine, described as H1-agonist (in guinea pig ileum) and H3-autoreceptor antagonist (in rat cerebral cortex) slightly decreased the EEC, but competitively inhibited the histamine effect. 4. The results obtained suggest the existence of a specific third type presynaptic H-receptors in rat vas deferens, which are pharmacologically similar to the presynaptic H3-autoreceptors in rat cerebral cortex.

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Year:  1991        PMID： 1657688     DOI： 10.1016/0306-3623(91)90070-m

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  6 in total

1.  Receptor subtypes involved in the modulatory action of histamine on the contractility of the rat vas deferens.

Authors:  R Zamfirova; S Todorov
Journal:  Inflamm Res       Date:  1995-04       Impact factor: 4.575

2.  Presynaptic histamine H2 receptors modulate the sympathetic nerve transmission in the isolated rat vas deferens; no role for H3-receptors.

Authors:  E Poli; S Todorov; C Pozzoli; G Bertaccini
Journal:  Agents Actions       Date:  1994-10

3.  Inhibition of noradrenaline release from the sympathetic nerves of the human saphenous vein by presynaptic histamine H3 receptors.

Authors:  G J Molderings; G Weissenborn; E Schlicker; J Likungu; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-07       Impact factor: 3.000

4.  Identification of endothelial H1, vascular H2 and cardiac presynaptic H3 receptors in the pithed rat.

Authors:  B Malinowska; E Schlicker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

5.  A comparison of histamine effects on the sympathetic neurotransmission of testicular capsule and rat vas deferens.

Authors:  Edilson Dantas da Silva Júnior; Juliano Quintella Dantas Rodrigues; Bruno Palmieri de Souza; Afonso Caricati-Neto; Aron Jurkiewicz; Neide H Jurkiewicz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-04-16       Impact factor: 3.000

6.  Activation of histamine H3 receptors produces presynaptic inhibition of neurally evoked cat nictitating membrane responses in vivo.

Authors:  M C Koss; J A Hey
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-08       Impact factor: 3.000
  6 in total

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