| Literature DB >> 16574216 |
Linden D Bolisay1, James N Culver, Peter Kofinas.
Abstract
Molecular imprinted Polymers (MIP) targeted for Tobacco mosaic virus (TMV) have been synthesized. Batch equilibrium studies using imprinted and non-imprinted polymer hydrogels in TMV and TNV solutions were conducted to determine virus-binding capacities. TMV-imprinted hydrogels showed increased binding to TMV (8.8 mg TMV/gpolymer) compared to non-imprinted hydrogels (4.2 mg TMV/gpolymer). Furthermore, TMV-imprinted hydrogels exhibited increased binding to TMV compared to TNV, while non-imprinted hydrogels bound similar amounts of TMV or TNV. This research has demonstrated that molecular imprinting of viruses can be used to selectively induce binding of target viruses based on shape differences of their virions.Entities:
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Year: 2006 PMID： 16574216 DOI： 10.1016/j.biomaterials.2006.03.018
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479