Literature DB >> 1657349

Neuronal loss in a lower motor neuron disease induced by a murine retrovirus.

P Jolicoeur1.   

Abstract

An animal model of neuronal loss induced by a murine retrovirus is described. The neurological disease is manifested by a lower limb paralysis and is characterized as a spongiform myeloencephalopathy. The primary determinant of neurovirulence has been mapped within the viral env sequences and a secondary determinant is present within the LTR region. A model of pathogenesis, suggesting that the disease is receptor-mediated, is proposed.

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Year:  1991        PMID： 1657349     DOI： 10.1017/s031716710003256x

Source DB:  PubMed          Journal:  Can J Neurol Sci        ISSN： 0317-1671            Impact factor:   2.104


  6 in total

1.  Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.

Authors:  Tobias Paprotka; Narasimhan J Venkatachari; Chawaree Chaipan; Ryan Burdick; Krista A Delviks-Frankenberry; Wei-Shau Hu; Vinay K Pathak
Journal:  J Virol       Date:  2010-03-24       Impact factor: 5.103

2.  Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis.

Authors:  Renée Douville; Jiankai Liu; Jeffrey Rothstein; Avindra Nath
Journal:  Ann Neurol       Date:  2011-01       Impact factor: 10.422

3.  The prion protein gene is dispensable for the development of spongiform myeloencephalopathy induced by the neurovirulent Cas-Br-E murine leukemia virus.

Authors:  P Jolicoeur; G Massé; D G Kay
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

4.  Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR.

Authors:  Samuel L Murphy; Marek J Honczarenko; Natalie V Dugger; Paul M Hoffman; Glen N Gaulton
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

5.  Development of physical forms of unintegrated retroviral DNA in mouse spinal cord tissue during ts1-induced spongiform encephalomyelopathy: elevated levels of a novel single-stranded form in paralyzed mice.

Authors:  P F Szurek; B R Brooks
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103

6.  Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes.

Authors:  Paul Jolicoeur; Chunyan Hu; Tak W Mak; Jean-Claude Martinou; Denis G Kay
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103
  6 in total

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