Continuous veno-venous haemodiafiltration in sodium valproate overdose complicated by cerebral oedema: a case report.

A case of severe sodium valproate overdose is presented in which continuous venovenous haemodiafiltration was used. However, following the commencement of dialysis and a fall in the serum valproate levels, the patient developed cerebral oedema. This case demonstrated a poor correlation between serum valproate and its toxic effects and the lack of benefit of continuous venovenous haemodiafiltration in the management of sodium valproate overdose.