Literature DB >> 16572900

Chemosensitization effects of XIAP downregulation in K562 leukemia cells.

R T Lima1, L M Martins, J E Guimarães, C Sambade, M H Vasconcelos.   

Abstract

The effect of downregulation of the expression of the antiapoptotic protein XIAP with antisense oligonucleotides was evaluated in the K562 chronic myeloid leukemia (CML) cell line. This was carried out by studying the effects of downregulation of XIAP expression on cellular viability, cellular apoptosis and on the response to two chemotherapeutical drugs, etoposide and doxorubicin. We document that downregulation of XIAP expression decreased cellular viability, increased cellular apoptosis and enhanced the effects of doxorubicin.

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Year:  2006        PMID： 16572900     DOI： 10.1179/joc.2006.18.1.98

Source DB:  PubMed          Journal:  J Chemother        ISSN： 1120-009X            Impact factor:   1.714


  3 in total

1.  microRNA-192-5p is involved in nerve repair in rats with peripheral nerve injury by regulating XIAP.

Authors:  Xing Liu; Xintao Cui; Guangwei Guan; Ying Dong; Zhenyu Zhang
Journal:  Cell Cycle       Date:  2020-01-16       Impact factor: 4.534

2.  Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles.

Authors:  Vanessa Lopes-Rodrigues; Alessio Di Luca; Justyna Mleczko; Paula Meleady; Michael Henry; Milica Pesic; Diana Cabrera; Sebastiaan van Liempd; Raquel T Lima; Robert O'Connor; Juan M Falcon-Perez; M Helena Vasconcelos
Journal:  Sci Rep       Date:  2017-03-17       Impact factor: 4.379

3.  The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia.

Authors:  Gabriela Nestal de Moraes; Paloma Silva Souza; Fernanda Casal de Faria Costas; Flavia Cunha Vasconcelos; Flaviana Ruade Souza Reis; Raquel Ciuvalschi Maia
Journal:  Leuk Res Treatment       Date:  2012-04-24
  3 in total

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