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Literature DB >> 1657186

Nucleotide sequences of three different isoforms of beta-tubulin cDNA from Chinese hamster ovary cells.

Abstract

The complete cDNA sequences of two clones encoding beta-tubulin isotypes and the partial sequence of a third isoform from Chinese hamster ovary cells have been determined. The deduced amino acid sequences of the three isoforms show extensive homology to each other as well as with other alpha and beta-tubulin sequences from various species. These results provide evidence for the expression of three different isoforms of beta-tubulin in Chinese hamster ovary cells.

Entities: Gene Species

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Year: 1991 PMID： 1657186 DOI： 10.1016/0167-4781(91)90112-y

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

11 in total

1. A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation.

Authors: Rajat Bhattacharya; Fernando Cabral
Journal: Mol Biol Cell Date: 2004-04-30 Impact factor: 4.138

2. Mutations affecting beta-tubulin folding and degradation.

Authors: Yaqing Wang; Guoling Tian; Nicholas J Cowan; Fernando Cabral
Journal: J Biol Chem Date: 2006-03-22 Impact factor: 5.157

3. Molecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance.

Authors: Rajat Bhattacharya; Fernando Cabral
Journal: J Biol Chem Date: 2009-03-12 Impact factor: 5.157

Review 4. Are tubulin isotypes functionally significant.

Authors: R F Ludueña
Journal: Mol Biol Cell Date: 1993-05 Impact factor: 4.138

5. Megakaryocyte lineage-specific class VI β-tubulin suppresses microtubule dynamics, fragments microtubules, and blocks cell division.

Authors: Hailing Yang; Anutosh Ganguly; Shanghua Yin; Fernando Cabral
Journal: Cytoskeleton (Hoboken) Date: 2011-03

6. Use of N,N'-polymethylenebis(iodoacetamide) derivatives as probes for the detection of conformational differences in tubulin isotypes.

Authors: J Sharma; R F Ludueña
Journal: J Protein Chem Date: 1994-02

Nucleotide sequences of three different isoforms of beta-tubulin cDNA from Chinese hamster ovary cells.

1. A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation.

2. Mutations affecting beta-tubulin folding and degradation.

3. Molecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance.

Review 4. Are tubulin isotypes functionally significant.

5. Megakaryocyte lineage-specific class VI β-tubulin suppresses microtubule dynamics, fragments microtubules, and blocks cell division.

6. Use of N,N'-polymethylenebis(iodoacetamide) derivatives as probes for the detection of conformational differences in tubulin isotypes.

7. Human mutations that confer paclitaxel resistance.

8. Random mutagenesis of β-tubulin defines a set of dispersed mutations that confer paclitaxel resistance.

9. Class V β-tubulin alters dynamic instability and stimulates microtubule detachment from centrosomes.

10. Class III β-tubulin counteracts the ability of paclitaxel to inhibit cell migration.