Literature DB >> 16571839

Murine cytomegalovirus interference with antigen presentation contributes to the inability of CD8 T cells to control virus in the salivary gland.

Xiuju Lu1, Amelia K Pinto, Ann M Kelly, Kathy S Cho, Ann B Hill.   

Abstract

Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivary gland is uniquely resistant to CD8 T-cell control. The contribution of viral genes that interfere with antigen presentation (VIPRs) to this resistance was assessed using a mutant lacking MCMV's known VIPRs. Salivary gland titers of the VIPR-deficient virus were at least 10-fold lower than those of the wild type during the persistent phase of infection; the defect was reversed by depleting CD8 T cells. Thus, VIPRs contribute to CD8 T cells' inability to control virus in the salivary gland.

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Year:  2006        PMID： 16571839      PMCID： PMC1440476          DOI： 10.1128/JVI.80.8.4200-4202.2006

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

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Authors:  H Hengel; U Reusch; G Geginat; R Holtappels; T Ruppert; E Hellebrand; U H Koszinowski
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

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Authors:  Rafaela Holtappels; Doris Thomas; Jürgen Podlech; Matthias J Reddehase
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Review 3.  Viral interference with antigen presentation.

Authors:  Jonathan W Yewdell; Ann B Hill
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Authors:  Amelia K Pinto; Ann B Hill
Journal:  Viral Immunol       Date:  2005       Impact factor: 2.257

5.  Processing and presentation of murine cytomegalovirus pORFm164-derived peptide in fibroblasts in the face of all viral immunosubversive early gene functions.

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Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

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Authors:  Marielle C Gold; Michael W Munks; Markus Wagner; Christopher W McMahon; Ann Kelly; Daniel G Kavanagh; Mark K Slifka; Ulrich H Koszinowski; David H Raulet; Ann B Hill
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Journal:  J Virol       Date:  2003-02       Impact factor: 5.103

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Authors:  A Krmpotic; M Messerle; I Crnkovic-Mertens; B Polic; S Jonjic; U H Koszinowski
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  22 in total

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Authors:  Ramon Arens; Andrea Loewendorf; Min J Her; Kirsten Schneider-Ohrum; Geoffrey R Shellam; Edith Janssen; Carl F Ware; Stephen P Schoenberger; Chris A Benedict
Journal:  J Virol       Date:  2010-10-27       Impact factor: 5.103

2.  Cytomegalovirus encodes a positive regulator of antigen presentation.

Authors:  Rafaela Holtappels; Dorothea Gillert-Marien; Doris Thomas; Jürgen Podlech; Petra Deegen; Sylvia Herter; Silke A Oehrlein-Karpi; Dennis Strand; Markus Wagner; Matthias J Reddehase
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Authors:  Verena Böhm; Christof K Seckert; Christian O Simon; Doris Thomas; Angélique Renzaho; Dorothea Gendig; Rafaela Holtappels; Matthias J Reddehase
Journal:  J Virol       Date:  2009-07-15       Impact factor: 5.103

5.  A CD4+ T Cell-NK Cell Axis of Gammaherpesvirus Control.

Authors:  Clara Lawler; Philip G Stevenson
Journal:  J Virol       Date:  2020-01-17       Impact factor: 5.103

6.  Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells.

Authors:  M Zeeshan Chaudhry; Rosaely Casalegno-Garduno; Katarzyna M Sitnik; Bahram Kasmapour; Ann-Kathrin Pulm; Ilija Brizic; Britta Eiz-Vesper; Andreas Moosmann; Stipan Jonjic; Edward S Mocarski; Luka Cicin-Sain
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Journal:  J Virol       Date:  2009-11-11       Impact factor: 5.103

Review 8.  Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions.

Authors:  Niels A W Lemmermann; Annette Fink; Jürgen Podlech; Stefan Ebert; Vanessa Wilhelmi; Verena Böhm; Rafaela Holtappels; Matthias J Reddehase
Journal:  Med Microbiol Immunol       Date:  2012-09-09       Impact factor: 3.402

9.  Intranasal immunization with recombinant vesicular stomatitis virus expressing murine cytomegalovirus glycoprotein B induces humoral and cellular immunity.

Authors:  Steven R Wilson; Jean H Wilson; Linda Buonocore; Amy Palin; John K Rose; Jon D Reuter
Journal:  Comp Med       Date:  2008-04       Impact factor: 0.982

Review 10.  MHC class I immune evasion in MCMV infection.

Authors:  Carmen M Doom; Ann B Hill
Journal:  Med Microbiol Immunol       Date:  2008-03-11       Impact factor: 3.402
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