| Literature DB >> 16570931 |
Joni K O Alvesalo1, Antti Siiskonen, Mikko J Vainio, Päivi S M Tammela, Pia M Vuorela.
Abstract
High throughput screening drug discovery utilizes large and expensive compound libraries. As an alternative, a smaller targeted library can be constructed with the aid of the 3D structure of the target molecule. We used the X-ray crystal structure of a protein homologous to the selected target in creation of a small focused library and evaluated inhibition potential of this library against Chlamydia pneumoniae, a common pathogen recently linked to atherosclerosis and risk of myocardial infarction.Entities:
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Year: 2006 PMID： 16570931 DOI： 10.1021/jm051209w
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446