Literature DB >> 1657006

In vitro effect of nonsteroidal antiinflammatory drugs on proteoglycanase and collagenase activity in human osteoarthritic cartilage.

E Vignon1, P Mathieu, P Louisot, M Richard.   

Abstract

The effects of several nonsteroidal antiinflammatory drugs, used at concentrations achievable in synovial fluid, on human osteoarthritic (OA) cartilage metallo-protease activity in vitro was studied. Acetaminophen and ketoprofen had no effect; sodium salicylate, indomethacin, and diclofenac slightly decreased proteoglycanase activity. Piroxicam and tenoxicam suppressed proteoglycanase activity by 48.2% and 68.3%, respectively, and suppressed collagenase activity by 19.1% and 36.8%, respectively. Use of these NSAIDs may help to decrease cartilage catabolism in patients with OA.

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Year:  1991        PMID： 1657006     DOI： 10.1002/art.1780341021

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  11 in total

1.  Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human cartilage.

Authors:  L Blot; A Marcelis; J P Devogelaer; D H Manicourt
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

2.  Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage.

Authors:  J P Pelletier; J Martel-Pelletier
Journal:  Drugs       Date:  1993       Impact factor: 9.546

Review 3.  Nonsteroidal anti-inflammatory drugs and chondroprotection. A review of the evidence.

Authors:  P Ghosh
Journal:  Drugs       Date:  1993-11       Impact factor: 9.546

4.  The effect of intra-articular Tenoxicam on knee effusion after arthroscopy.

Authors:  Roger Jawish; Hassan Najdi; Claude Abi Safi; Ali Chameseddine
Journal:  Int Orthop       Date:  2015-01-06       Impact factor: 3.075

5.  Comparison of intra-articular tenoxicam and oral tenoxicam for pain and physical functioning in osteoarthritis of the knee.

Authors:  Zeliha Unlu; Kamuran Ay; Cigdem Tuzun
Journal:  Clin Rheumatol       Date:  2005-10-15       Impact factor: 2.980

6.  Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates aspirin-induced gastric mucosal injury in rats.

Authors:  Masaru Odashima; Michiro Otaka; Mario Jin; Koga Komatsu; Noriaki Konishi; Isao Wada; Youhei Horikawa; Tamotsu Matsuhashi; Reina Ohba; Jinko Oyake; Nastumi Hatakeyama; Sumio Watanabe
Journal:  Dig Dis Sci       Date:  2005-06       Impact factor: 3.199

7.  Interleukin-4 suppression of interleukin-1-induced transcription of collagenase (MMP-1) and stromelysin 1 (MMP-3) in human synovial fibroblasts.

Authors:  R C Borghaei; P L Rawlings; E Mochan
Journal:  Arthritis Rheum       Date:  1998-08

8.  Interleukin-4 suppresses IL-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts.

Authors:  Kosunique Jenkins; Masoud Javadi; Ruth Carter Borghaei
Journal:  J Periodontol       Date:  2004-02       Impact factor: 6.993

9.  Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage.

Authors:  D H Manicourt; A Druetz-Van Egeren; L Haazen; C Nagant de Deuxchaisnes
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739

10.  Experimental Study on Protective Role of NSAID on Articular Cartilage Destruction in Septic Arthritis.

Authors:  Seyed Mohammad Tahami; Amir Aminian; Negar Azarpira
Journal:  Arch Bone Jt Surg       Date:  2020-01
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