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Literature DB >> 16569872

Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.

Moses Prabu-Jeyabalan¹, Nancy M King, Ellen A Nalivaika, Gabrielle Heilek-Snyder, Nick Cammack, Celia A Schiffer.

Abstract

In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns.

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Year: 2006 PMID： 16569872 PMCID： PMC1426980 DOI： 10.1128/AAC.50.4.1518-1521.2006

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

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2. Combating susceptibility to drug resistance: lessons from HIV-1 protease.

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Authors: Moses Prabu-Jeyabalan; Ellen A Nalivaika; Nancy M King; Celia A Schiffer
Journal: J Virol Date: 2004-11 Impact factor: 5.103

6. Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.

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Authors: Dan Turner; Jonathan M Schapiro; Bluma G Brenner; Mark A Wainberg
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8. Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database.

Authors: R W Shafer; D Stevenson; B Chan
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9. Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor.

Authors: Nancy M King; Moses Prabu-Jeyabalan; Ellen A Nalivaika; Piet Wigerinck; Marie-Pierre de Béthune; Celia A Schiffer
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10. Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy.

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Journal: J Virol Date: 2003-01 Impact factor: 5.103

19 in total

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5. Kinetic characterization of the critical step in HIV-1 protease maturation.

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6. Identification of folding preferences of cleavage junctions of HIV-1 precursor proteins for regulation of cleavability.

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7. Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.

Authors: Nancy M King; Moses Prabu-Jeyabalan; Rajintha M Bandaranayake; Madhavi N L Nalam; Ellen A Nalivaika; Ayşegül Özen; Türkan Haliloğlu; Neşe Kurt Yilmaz; Celia A Schiffer
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8. The challenge of developing robust drugs to overcome resistance.

Authors: Amy C Anderson; Michael P Pollastri; Celia A Schiffer; Norton P Peet
Journal: Drug Discov Today Date: 2011-07-19 Impact factor: 7.851

9. Crystal structure of lysine sulfonamide inhibitor reveals the displacement of the conserved flap water molecule in human immunodeficiency virus type 1 protease.

Authors: Madhavi N L Nalam; Anik Peeters; Tim H M Jonckers; Inge Dierynck; Celia A Schiffer
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10. New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors.

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