Literature DB >> 1656956

Specific endonucleolytic cleavage of IGF-II mRNAs.

D Meinsma1, P E Holthuizen, J L Van den Brande, J S Sussenbach.   

Abstract

Expression of the human insulin-like growth factor II (IGF-II) gene gives rise to a family of mRNAs which are expressed in a tissue- and developmental-specific manner. Recently, an IGF-II RNA species of 1.8 kb was detected which consists of the 3' terminal untranslated region of the last IGF-II exon. We have investigated the mechanism of formation of this RNA employing IGF-II minigenes. Analysis of the expression of these genes has revealed that the 1.8-kb RNA does not result from transcription activation, but arises by specific cleavage of IGF-II transcripts.

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Year:  1991        PMID： 1656956     DOI： 10.1016/0006-291x(91)91743-v

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

Review 1.  A systematic analysis of disease-associated variants in the 3' regulatory regions of human protein-coding genes II: the importance of mRNA secondary structure in assessing the functionality of 3' UTR variants.

Authors:  Jian-Min Chen; Claude Férec; David N Cooper
Journal:  Hum Genet       Date:  2006-06-29       Impact factor: 4.132

2.  Characterization of nuclear RNases that cleave hepatitis B virus RNA near the La protein binding site.

Authors:  T Heise; L G Guidotti; F V Chisari
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

3.  A novel synapse-associated noncoding RNA.

Authors:  M A Velleca; M C Wallace; J P Merlie
Journal:  Mol Cell Biol       Date:  1994-11       Impact factor: 4.272

Review 4.  mRNA stability in mammalian cells.

Authors:  J Ross
Journal:  Microbiol Rev       Date:  1995-09

5.  Growth-condition-dependent regulation of insulin-like growth factor II mRNA stability.

Authors:  W Scheper; P E Holthuizen; J S Sussenbach
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

6.  Kinetics and regulation of site-specific endonucleolytic cleavage of human IGF-II mRNAs.

Authors:  E L van Dijk; J S Sussenbach; P E Holthuizen
Journal:  Nucleic Acids Res       Date:  2001-09-01       Impact factor: 16.971

7.  Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP.

Authors:  Latifa Zekri; Karim Chebli; Hélène Tourrière; Finn C Nielsen; Thomas V O Hansen; Abdelhaq Rami; Jamal Tazi
Journal:  Mol Cell Biol       Date:  2005-10       Impact factor: 4.272

8.  Identification of RNA sequences and structures involved in site-specific cleavage of IGF-II mRNAs.

Authors:  E L van Dijk; J S Sussenbach; P E Holthuizen
Journal:  RNA       Date:  1998-12       Impact factor: 4.942

9.  Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene.

Authors:  D Meinsma; W Scheper; P E Holthuizen; J L Van den Brande; J S Sussenbach
Journal:  Nucleic Acids Res       Date:  1992-10-11       Impact factor: 16.971

10.  A guanosine quadruplex and two stable hairpins flank a major cleavage site in insulin-like growth factor II mRNA.

Authors:  J Christiansen; M Kofod; F C Nielsen
Journal:  Nucleic Acids Res       Date:  1994-12-25       Impact factor: 16.971
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