Literature DB >> 16568989

Kinetic resolution of protected alpha-amino acid derivatives by a chiral O-nucleophilic acyl transfer catalyst.

Gregory T Notte1, Tarek Sammakia.   

Abstract

The kinetic resolution of alpha-trifluoroacetamido N-acyl oxazolidinethiones using 5-10% of the chiral, nonracemic O-nucleophilic acyl transfer catalyst 2 is described. A variety of substrates participate in this reaction in excellent yields, with s-factors ranging from 20 to 86.

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Year:  2006        PMID: 16568989     DOI: 10.1021/ja058010t

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  1 in total

1.  Homobenzotetramisole-Catalyzed Kinetic Resolution of alpha-Aryl-, alpha-Aryloxy-, and alpha-Arylthioalkanoic Acids.

Authors:  Xing Yang; Vladimir B Birman
Journal:  Adv Synth Catal       Date:  2009       Impact factor: 5.837

  1 in total

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